Results 151 to 160 of about 1,666,541 (346)

Determinants of viral load suppression among adolescents on antiretroviral therapy in Eswatini: a cross-sectional study

BMC Infectious Diseases
Background The goal of antiretroviral therapy (ART) is to achieve a sustained HIV suppressed viral load. However, adolescents often present poor adherence to ART which is associated with lower rates of viral load suppression (VLS).
Londiwe D. Hlophe, Constance S. Shumba, Diribsa T. Bedada, Peter S. Nyasulu   +3 more
doaj   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Clinical predictors and correlates of viral suppression among adults accessing care at the HIV clinic in federal medical center, Abeokuta, Ogun state, Nigeria: a retrospective cohort study

BMC Infectious Diseases
Background Globally, Human Immune-deficiency Virus (HIV) continues to be one of the world’s most significant public health issues. At the end of 2022, 39.0 million people were living with HIV (PLHIV) worldwide with 9% resident in Nigeria.
Mobolaji Modinat Salawu, Yusuff Akinkunmi Olasunkanmi, Omowumi Omolola Okedare, Gloria Bosede Imhonopi   +3 more
doaj   +1 more source

Anti-viral activity of acetylsalicylic acid against human rhinovirus 14 infection involves suppression of VP3 expression and infection-dependent down-regulation of CD54

, 2022
Bernadette Glatthaar‐Saalmüller, Armin Saalmüller, Kerstin H. Mair   +2 more
openalex   +1 more source

Depression and Viral Suppression Among Adults Living with HIV in Tanzania

Aids and Behavior, 2021
M. Regan, A. Muhihi, T. Nagu, S. Aboud, Nzovu K Ulenga, S. Kaaya, M. C. Fawzi, A. Yousafzai, F. Mugusi, W. Fawzi, S. Saxena, K. Koenen, C. Sudfeld   +12 more
semanticscholar   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Time to viral load suppression and its predictors among people living with HIV on antiretroviral therapy in Gebi Resu zone, Afar Region, Ethiopia, 2023

Frontiers in Public Health
ObjectiveThis study aimed to estimate the time to viral load suppression and identify its predictors among HIV patients receiving antiretroviral therapy (ART) in the Gebi Resu zone, Afar Region, Ethiopia, 2023.SettingThe study was conducted at public ...
Anteneh Tefera Chirnet, Ephrem Mannekulih Habtewold, Haji Aman, Elias Bekele Wakwoya, Sewnet Getaye Workie   +4 more
doaj   +1 more source

Early Intensification with Abacavir in Subjects at High Risk for Incomplete Viral Suppression [PDF]

, 2003
John Bartlett, Pablo Tebas, Roland L. Bassett, Wenzheng Huang, Daniel R. Kuritzkes, Ronald B. Reisler, Nancy Loyack, Kellye Robison, Paulette MacDougall, Pualani Kondo, Terrence F. Blaschke, Bernadette Jarocki, Jeffrey Giardini, Lynette Purdue, Seth Hetherington, Katherine E. Baker, Jules Levin, Janet Nicotera, Vicki Bailey, Philip Keiser, Tianna Petersen, David Ragan, Jane Reid, Carol Greisberger, Carol Greisberger   +24 more
openalex   +1 more source