Results 201 to 210 of about 1,274,523 (300)

Changes in HIV Clinical Visit Frequency and Viral Suppression During and After COVID-19 Restrictions: A Nested Study Within NA-ACCORD in the US, 2018-2021. [PDF]

Open Forum Infect Dis
Zhang Y, Hogan BC, Gebo KA, Rebeiro PF, Wainberg ML, Lesko CR, Marconi VC, Shah NS, Lang R, Haw NJL, Cheng Y, Horberg MA, Lam JO, Silverberg MJ, Yendewa G, Eron JJ, Moore RD, Parcesepe AM, Althoff KN, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) .   +20 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Baseline Data on Viral Suppression, Treatment Adherence and Mental Health in Peripartum Girls and Young Women With HIV in Zimbabwe. [PDF]

J Int AIDS Soc
Chawana-Mutingwende TD, Ngara B, Mudadi LS, Tauya TT, Sibanda M, Mutambanengwe-Jacob M, Andifasi P, Malunda B, Chidemo T, Mapfunde A, Nyakudya S, Mufumisi AZ, Chirenda TH, Chitambo T, Nderecha WTS, Murandu C, Gwande M, Muringayi K, Micah Bongo R, Okochi H, Kuncze K, Mushavi A, Willis N, Webb K, Gandhi M, Stranix-Chibanda L.   +25 more
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Antiretroviral regimen switch and short-term viral suppression in persistent low-level viremia: A multicenter retrospective real-world cohort study in China. [PDF]

PLoS One
Liu H, Ren Y, Jia L, Wang L, Wang R, Yang T, Zhou Y, Zhao H, Dai L.   +8 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Viral suppression is associated with rising NT-proCNP levels and reduced systemic inflammation in people living with HIV. [PDF]

Infection
Bojti I, Bojtine Kovacs S, Ziegler A, Jung N, Maier A, Westermann D, Funk JL, Mathé P, Fink G, Usadel S, Rieg S, Szabo GT, Czuriga D, Müller MC.   +13 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

The Impact of HIV Viral Suppression and Immune Status on Rifampicin-Resistant Tuberculosis Outcomes: A Systematic Review and Meta-Analysis Protocol. [PDF]

Trop Med Infect Dis
Mphahlele T, Makhado TG, Makhado L.
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source