Results 121 to 130 of about 1,490,578 (344)

Assessment of packed bed bioreactor systems in the production of viral vaccines

AMB Express, 2014
Vaccination is believed to be the most effective method for the prevention of infectious diseases. Thus it is imperative to develop cost effective and scalable process for the production of vaccines so as to make them affordable for mass use.
Ramya Rajendran, Rajendra Lingala, Siva Kumar Vuppu, Bala Obulapathi Bandi, Elaiyaraja Manickam, Sankar Rao Macherla, S. Dubois, N. Havelange, K. Maithal   +8 more
semanticscholar   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Impact of Climate and Environmental Factors on West Nile Virus Circulation in Iran

Journal of Arthropod-Borne Diseases, 2016
Background: Geographic distribution of West Nile virus (WNV) is heterogeneous in Iran by a high circulation in the southern-western areas. The objective of our study was to determine environmental and climatic factors associ­ated with the risk of WNV ...
Farzaneh Ahmadnejad, Vahid Otarod, Amanollah Fathnia, Ali Ahmadabadi, Mohammad H. Fallah, Alireza Zavareh, Nargess Miandehi, Benoit Durand, Philippe Sabatier   +8 more
doaj  

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

The basics of viral vaccines

South African Family Practice, 2006
The family practitioner plays an important role in preventing disease. An estimated two million people die globally from vaccine-preventable diseases each year.
K. Richter
doaj   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Sero-Epidemiology and Evaluation of First Self-Prepared Bovine Viral Diarrhea Virus Vaccine in Cattle of Punjab, Pakistan

, 2023
Quratul Ain, A. Ahmad, Farhat Nazir Awan, M. Rabbani, M. Hassan Mushtaq   +4 more
openalex   +1 more source

Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens [PDF]

, 2020
Laura Arribillaga, Iciar Echeverria, Viriginia Belsue, Timothy S. Gomez, Teresa Lozano, Noëlia Casares, Lorea Villanueva, Sonia Domingos‐Pereira, Pedro Romero, Denise Nardelli‐Haefliger, Sandra Hervás‐Stubbs, Pablo Sarobe, María Josefa Rodríguez, José L. Carrascosa, Thomas Zürcher, Juan José Lasarte   +15 more
openalex   +1 more source

CXCR3+ T Follicular Helper Cells Induced by Co-Administration of RTS,S/AS01B and Viral-Vectored Vaccines Are Associated With Reduced Immunogenicity and Efficacy Against Malaria

Frontiers in Immunology, 2018
A malaria vaccine strategy targeting multiple lifecycle stages may be required to achieve a high level of efficacy. In two Phase IIa clinical trials, we tested immunogenicity and efficacy of RTS,S/AS01B administered alone, in a staggered regimen with ...
Georgina S. Bowyer, Amy Grobbelaar, T. Rampling, N. Venkatraman, D. Morelle, R. Ballou, A. Hill, K. Ewer   +7 more
semanticscholar   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source