Results 101 to 110 of about 1,005,947 (300)

mRNA Vaccine Development in the Fight Against Zoonotic Viral Diseases

Zoonotic diseases are transmitted from animals to humans, and they impose a significant global burden by impacting both animal and human health. It can lead to substantial economic losses and cause millions of human deaths. The emergence and re-emergence
Chit Laa Poh, Seng Kong Tham, Brandon E. K. Tan   +2 more
core   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Characterization of a synthetic infectious cloned DNA of simian foamy virus serotype 1

npj Viruses
A virus stock of a cloned infectious DNA of simian foamy virus serotype 1 (SFV-1) was obtained in M. dunni cells (designated as pSFV-MD). The kinetics of replication were similar to the parent uncloned SFV-MD stock in M.
Sandra M. Fuentes, Nicholas Mattson, Trent J. Bosma, Eunhae H. Bae, Arifa S. Khan   +4 more
doaj   +1 more source

Two RSV Platforms for G, F, or G+F Proteins VLPs

, 2020
Respiratory syncytial virus (RSV) causes substantial lower respiratory tract disease in children and at-risk adults. Though there are no effective anti-viral drugs for acute disease or licensed vaccines for RSV, palivizumab prophylaxis is available for ...
Xuemin Chen, Larry J. Anderson, Samadhan J. Jadhao, Jie E. Yang, Elizabeth R. Wright, Binh Ha   +5 more
core   +1 more source

Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses

, 2021
Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates and herpes keratitis to orofacial and genital herpes, among other manifestations.
Gershburg, Edward, Brent A. Stanfield, Fernandez, Agustin, Stanfield, Brent A, Kousoulas, Konstantin G, Agustin Fernandez, Konstantin G. Kousoulas, Edward Gershburg   +7 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Understanding and explaining viral vector COVID-19 vaccines [PDF]

Several COVID-19 vaccine candidates entering late-stage clinical trials are what is known as viral vector vaccines. These vaccines are likely to be among the COVID-19 vaccines authorized for use in the United States.

core  

Specificity of DNA Vaccines against the Genogroup J and U Infectious Hematopoietic Necrosis Virus Strains Prevalent in China

, 2022
Infectious hematopoietic necrosis virus (IHNV) is the most important pathogen threatening the aquaculture of salmonid fish in China. In addition to the common genogroup J IHNV, genogroup U has been newly discovered in China.
Huanhuan Yu, Dandan Huang, Sun, Huiling, Tieliang Li, Wutong Lin, Huiling Sun, Yu, Huanhuan, Luo, Lin, Zhihong Ma, Caiyun Huo, Lin Luo, Lin, Wutong, Xing, Wei, Guiping Li, Guanling Xu, Ma, Zhihong, Xu, Guanling, Li, Guiping, Jiang, Na, Na Jiang, Huang, Dandan, Wei Xing, Huo, Caiyun, Li, Tieliang   +23 more
core   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Characterization of Chemically-Induced Endogenous Retroviral Particles in the CHO-K1 Cell Line

Viruses
The Chinese hamster ovary K1 cell line (CHO-K1) constitutively produces retroviral-like particles (RVLPs) containing reverse transcriptase (RT) activity, which, thus far, have not been shown to be infectious.
Nicholas B. Mattson, Trent J. Bosma, Yamei Gao, Sandra M. Fuentes, Pei-Ju Chin, Arifa S. Khan   +5 more
doaj   +1 more source