Results 211 to 220 of about 371,957 (300)

Safety, Pharmacokinetics, and Dose Recommendations for Nirmatrelvir/Ritonavir in Individuals with Mild to Moderate COVID‐19 and Severe Renal Impairment

Clinical Pharmacology &Therapeutics, EarlyView.
Patients with severe renal impairment and COVID‐19 are at high risk for severe disease and death. Nirmatrelvir/ritonavir, an antiviral therapy for COVID‐19, is eliminated by renal excretion and can accumulate in patients with severe renal impairment.
Jacqueline Gerhart, Candace R. Bramson, Michelle Goulding, Haihong Shi, Olayide Oladoyinbo, Phylinda L. S. Chan, Sunring Chime, Jennifer Hammond   +7 more
wiley   +1 more source

Viral vaccines promote endoplasmic reticulum stress-induced unfolding protein response in teleost erythrocytes.

Eur J Cell Biol
Salvador-Mira M, Gimenez-Moya P, Manso-Aznar A, Sánchez-Córdoba E, Sevilla-Diez MA, Chico V, Nombela I, Puente-Marin S, Roher N, Perez L, Dučić T, Benseny-Cases N, Perez-Berna AJ, Ortega-Villaizan MDM.   +13 more
europepmc   +1 more source

Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films. [PDF]

Sci Rep, 2019
Leung V, Mapletoft J, Zhang A, Lee A, Vahedi F, Chew M, Szewczyk A, Jahanshahi-Anbuhi S, Ang J, Cowbrough B, Miller MS, Ashkar A, Filipe CDM.   +12 more
europepmc   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, EarlyView.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Corrigendum to "Viral vaccines promote endoplasmic reticulum stress-induced unfolding protein response in teleost erythrocytes" [Eur. J. Cell Biol. 104 (2025) 151490].

Eur J Cell Biol
Salvador-Mira M, Gimenez-Moya P, Manso-Aznar A, Sánchez-Córdoba E, Sevilla-Diez MA, Chico V, Nombela I, Puente-Marin S, Roher N, Perez L, Dučić T, Benseny-Cases N, Perez-Berna AJ, Ortega-Villaizan MDM.   +13 more
europepmc   +1 more source

How the gut microbiome regulates host immune responses to viral vaccines. [PDF]

Curr Opin Virol, 2019
Vlasova AN, Takanashi S, Miyazaki A, Rajashekara G, Saif LJ.   +4 more
europepmc   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Structural Motifs, Disorder, and the Efficacy of Viral Vaccines

, 2020
Makin RA, Durbin SM.
europepmc   +1 more source

From prevention to cure, repurposing anti-viral vaccines for cancer immunotherapy. [PDF]

Biotarget, 2018
Mamai O, Dodagatta-Marri E, Akhurst RJ.
europepmc   +1 more source

Vaccination Against Tuberculosis: Revamping BCG by Molecular Genetics Guided by Immunology

, 2020
Kaufmann, S.
core   +1 more source