Results 91 to 100 of about 2,747,170 (398)

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

open access: yesAdvanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi   +4 more
wiley   +1 more source

An Improved Protocol for the Production of Lentiviral Vectors

open access: yesSTAR Protocols, 2020
Summary: Lentiviral vectors are an ideal gene-delivery system for large gene-editing tools, such as the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system, due to their high packaging capacity and broad tropism.
Logan Y. Brown, Wendy Dong, Boris Kantor
doaj  

Viral epidemiology of the adult Apis Mellifera infested by the Varroa destructor mite [PDF]

open access: yes, 2016
The ectoparasitic mite Varroa destructor has become one of the major worldwide threats for apiculture. Varroa destructor attacks the honey bee Apis mellifera weakening its host by sucking hemolymph.
Bernardi, Sara, Venturino, Ezio
core   +3 more sources

Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

open access: yesNature Communications, 2018
Heart rate is under the precise control of the autonomic nervous system. However, the wiring of peripheral neural circuits that regulate heart rate is poorly understood.
Pradeep S. Rajendran   +15 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Developments in Viral Vector-Based Vaccines [PDF]

open access: yesVaccines, 2014
Viral vectors are promising tools for gene therapy and vaccines. Viral vector-based vaccines can enhance immunogenicity without an adjuvant and induce a robust cytotoxic T lymphocyte (CTL) response to eliminate virus-infected cells. During the last several decades, many types of viruses have been developed as vaccine vectors.
Kenji Okuda   +2 more
openaire   +3 more sources

Rustrela Virus-Associated Encephalomyelitis (‘Staggering Disease’) in Cats from Eastern Austria, 1994–2016

open access: yesViruses, 2023
Clinical cases of ‘staggering disease’, a nonsuppurative encephalomyelitis associated with gait abnormalities in cats, have been documented for decades in Sweden. In Austria, an increased incidence was observed in the 1990s. Only recently, rustrela virus
Viktoria Weiss   +5 more
doaj   +1 more source

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

open access: yes, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna   +3 more
core   +1 more source

Foxtail mosaic virus: A Viral Vector for Protein Expression in Cereals1[CC-BY]

open access: yesPlant Physiology, 2018
A foxtail mosaic virus vector allows the rapid expression of heterologous proteins of up to 600 amino acids in length in wheat and maize. Rapid and cost-effective virus-derived transient expression systems for plants are invaluable in elucidating gene ...
Clément R. Bouton   +6 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

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