Results 111 to 120 of about 2,747,170 (398)

Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola, Ralph Steinman, Richter C. King, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain

Gene Therapy, 2017
The present study was designed to characterize transduction of non-human primate brain and spinal cord with AAV5 viral vector after parenchymal delivery.
L. Samaranch, B. Blits, W. S. Sebastián, P. Hadaczek, J. Bringas, Vivek R. Sudhakar, M. Macayan, P. Pivirotto, H. Petry, K. Bankiewicz   +9 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. [PDF]

, 2010
The hnRNP C heterotetramer [(C1(3))C2] binds RNA polymerase II transcripts in the nucleus, along with other proteins of the core hnRNP complex, and plays an important role in mRNA biogenesis and transport.
Brunner, Jo Ellen, Ertel, Kenneth J, Rozovics, Janet M, Semler, Bert L   +3 more
core   +1 more source

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

EMBO Molecular Medicine, 2016
Gene therapy critically relies on vectors that combine high transduction efficiency with a high degree of target specificity and that can be administered through a safe intravenous route. The lack of suitable vectors, especially for gene therapy of brain
J. Körbelin, Godwin K. Dogbevia, S. Michelfelder, D. Ridder, A. Hunger, Jan Wenzel, H. Seismann, Melanie Lampe, Jacqueline Bannach, M. Pasparakis, J. Kleinschmidt, M. Schwaninger, M. Trepel   +12 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases

Frontiers in Molecular Neuroscience, 2020
Diseases of the central nervous system (CNS) have historically been among the most difficult to treat using conventional pharmacological approaches.
Joseph Edward Rittiner, Joseph Edward Rittiner, Joseph Edward Rittiner, Malik Moncalvo, Malik Moncalvo, Malik Moncalvo, Ornit Chiba-Falek, Ornit Chiba-Falek, Boris Kantor, Boris Kantor, Boris Kantor   +10 more
doaj   +1 more source

Murine leukemia virus (MLV) replication monitored with fluorescent proteins [PDF]

, 2006
Background: Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV) has been described to have potential as cancer therapeutics, however, MLV
Bittner, Alexandra, Erlwein, Otto, Schnierle, Barbara S., Sliva, Katja   +3 more
core  

Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors [PDF]

, 2013
There is an errata corrige made after the publication.Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors.
Capasso, Cristian, Cerullo, Vincenzo, Hirvinen, Mari   +2 more
core   +2 more sources

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy

Nature Communications, 2017
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTLeff) responses. Conversely, the induction of protective tumour-specific CTLeff and their recruitment into the tumour remain challenging tasks.
S. Kallert, Stephanie Darbre, Weldy V. Bonilla, M. Kreutzfeldt, Nicolas Page, P. Müller, M. Kreuzaler, Min Lu, S. Favre, F. Kreppel, M. Löhning, S. Luther, A. Zippelius, D. Merkler, D. Pinschewer   +14 more
semanticscholar   +1 more source