Results 121 to 130 of about 657,629 (304)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Seroprevalence of binding and neutralizing antibodies against 18 adeno-associated virus types in patients with neuromuscular disorders

Frontiers in Immunology
High levels of pre-existing antibodies are a major challenge for the application of viral vectors since they can severely limit their efficacy. To identify promising candidates among adeno-associated virus (AAV) based vectors for future gene therapies ...
Xiaoyan Wang, Patrick Julian Klann, Patrick Julian Klann, Ellen Wiedtke, Yumi Sano, Nico Fischer, Lisa Schiller, Anna Elfert, Anne-Katrin Güttsches, Ute Weyen, Dirk Grimm, Dirk Grimm, Matthias Vorgerd, Wibke Bayer   +13 more
doaj   +1 more source

195. Tat Peptide Conjugates of Low Molecular Weight Polyethylenimine as Effective Non-Viral Gene Delivery Vectors [PDF]

, 2006

openalex   +1 more source

Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors

, 2023
Timothy F. Shay, Erin E. Sullivan, Xiaozhe Ding, Xinhong Chen, Sripriya Ravindra Kumar, David Goertsen, David Alan Brown, Anaya Crosby, Jost Vielmetter, Máté Borsos, Damien A. Wolfe, Annie W. Lam, Viviana Gradinaru   +12 more
openalex   +1 more source

PLASMD BEARING A CDNA COPY OF THE GENOME OF BOVINE VIRAL DIARRHEA VIRUS, CHIMERIC DERIVATIVES THEREOF, AND METHOD OF PRODUCING AN INFECTIOUS BOVINE WRAL DARRHEAVIRUS USING SAD PLASMID [PDF]

, 1999
A plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus (BVDV), chimeric derivatives of the plasmid and a method of producing an infectious bovine viral diarrhea virus using the plasmid are disclosed. The invention relates to a plasmid
Donis, Ruben O., Vassilev, Ventzislav B.
core   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Imported dengue fever in South Korea, 2020–2024: Epidemiological trends and serotype distribution from national laboratory surveillance

Travel Medicine and Infectious Disease
Background: South Korea remains at risk for dengue virus (DENV) importation, primarily due to the widespread presence of Aedes albopictus and increasing international travel.
Ye-Ji Lee, Seung-Rye Cho, Won Kyong Kim, Myung Guk Han, Seon-Young Lee, So-dam Lee, Jonghee Kim, Heui Man Kim   +7 more
doaj   +1 more source

759. The Proto-Oncogene Evi1 (Ecotropic Viral Integration Site 1) Is a Common Insertion Site for Both Gammaretroviral and Lentiviral Vectors [PDF]

, 2009

openalex   +1 more source

3D Printing of Bacteriophage‐Loaded Hydrogels: Development of a Local and Long‐Lasting Delivery System

Advanced Healthcare Materials, EarlyView.
This research investigates the feasibility of 3D‐printing of a bacteriophage‐containing hydrogel made of alginate and methylcellulose. The printed hydrogels steadily release active bacteriophages for up to 35 days which is beneficial to treat implant‐associated infections.
Corina Vater, Gopala Krishna Mannala, Max von Witzleben, Richard Frank Richter, Nike Walter, Michael Gelinsky, Volker Alt, Anja Lode, Markus Rupp   +8 more
wiley   +1 more source

Efficiency for Gene Silencing Induction in Nicotiana Species by a Viral Satellite DNA Vector [PDF]

, 2007
You‐Ping Xu, Luping Zheng, Qiufang Xu, Changchun Wang, Xueping Zhou, Zujian Wu, Xin‐Zhong Cai   +6 more
openalex   +1 more source