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Viral Vectors for Veterinary Vaccines
Whatever strategy is adopted for the development of viral vectors for delivery of veterinary vaccines there are several key points to consider: (1) Will the vectored vaccine give a delivery advantage compared to what's already available? (2) Will the vectored vaccine give a manufacturing advantage compared to what's already available?
openaire +3 more sources
Replicon RNA Viral Vectors as Vaccines [PDF]
Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein genes and antigens.
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Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi+12 more
wiley +1 more source
LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]
Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA+5 more
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Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran+3 more
wiley +1 more source
Genetic Characterization of the Tick-Borne Orbiviruses
The International Committee for Taxonomy of Viruses (ICTV) recognizes four species of tick-borne orbiviruses (TBOs): Chenuda virus, Chobar Gorge virus, Wad Medani virus and Great Island virus (genus Orbivirus, family Reoviridae).
Manjunatha N. Belaganahalli+6 more
doaj +1 more source
Construction and characterization of H5N1-recombinant fowlpox viruses co-expressing host cytokines [PDF]
Possessing a large double stranded DNA genome up to 300 kb, fowlpox virus (FWPV) has been developed to express avian influenza virus (AIV) antigens since the late 1980s. A more advanced approach would be to coexpress host cytokines from such recombinants.
Abdul Razak, Mariatulqabtiah+1 more
core +1 more source
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki+11 more
wiley +1 more source
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hidetaka Akita+3 more
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Inquiries into Wheat Streak Mosaic Virus and Other WSM Associated Viruses [PDF]
Wheat Streak Mosaic WSM) is a complex disease found to cause severe impact on wheat yield. Wheat streak mosaic virus (WSMV Triticum Mosaic Virus (TMV) and Wheat Mosaic Virus (WMOV) are all transmitted by Aceria tosichella, the wheat cun mite, and have ...
Nouri, Shahdeh+3 more
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