Results 11 to 20 of about 1,876,696 (266)

Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy

Molecular Therapy: Methods & Clinical Development, 2021
To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptide ...
Dominique Van Looveren, Giorgia Giacomazzi, Irina Thiry, Maurilio Sampaolesi, Rik Gijsbers   +4 more
doaj   +1 more source

Blood-feeding, susceptibility to infection with Schmallenberg virus and phylogenetics of Culicoides (Diptera: Ceratopogonidae) from the United Kingdom

Parasites & Vectors, 2018
Background Culicoides biting midges (Diptera: Ceratopogonidae) are responsible for the biological transmission of internationally important arboviruses of livestock.
James Barber, Lara E. Harrup, Rhiannon Silk, Eva Veronesi, Simon Gubbins, Katarzyna Bachanek-Bankowska, Simon Carpenter   +6 more
doaj   +1 more source

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt, Nadine Müther, Ehrhardt, Anja, Nadja Noske, Müther, Nadine, Noske, Nadja, Nadine Müther   +6 more
core   +1 more source

An Improved Protocol for the Production of Lentiviral Vectors

STAR Protocols, 2020
Summary: Lentiviral vectors are an ideal gene-delivery system for large gene-editing tools, such as the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system, due to their high packaging capacity and broad tropism.
Logan Y. Brown, Wendy Dong, Boris Kantor
doaj   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco, Hallek, M., Michael Hallek, Buning, H., Braun-Falco, M., Hildegard Büning, Büning, H;Braun-Falco, M;Hallek, M, Büning, Hildegard;Braun-Falco, Markus;Hallek, Michael   +7 more
core   +1 more source

Clinical and Epidemiological Features of Actual Tick-Borne Infections under Conditions of Mass Vaccination against Tick-Borne Viral Encephalitis (by the Example of a Megapolis)

Эпидемиология и вакцинопрофилактика, 2023
Relevance. The clinical aspects of tick­borne viral encephalitis (TBE) and Lyme borrelliosis (LB) as monoinfections are well known. At the same time, the issues of interaction of pathogens in tick­borne encephalitis – Lyme borrelliosis mixed infection ...
V. A. Mishchenko, I. V. Vyalykh, A. G. Sergeev, I. P. Bykov, M. G. Toporkova, V. I. Chalapa   +5 more
doaj   +1 more source

Therapeutic modulation of gene expression in the disease state: Treatment strategies and approaches for the development of next-generation of the epigenetic drugs

Frontiers in Bioengineering and Biotechnology, 2022
Epigenetic dysregulation is an important determinant of many pathological conditions and diseases. Designer molecules that can specifically target endogenous DNA sequences provide a means to therapeutically modulate gene function.
Joseph Rittiner, Joseph Rittiner, Joseph Rittiner, Mohanapriya Cumaran, Mohanapriya Cumaran, Mohanapriya Cumaran, Sahil Malhotra, Sahil Malhotra, Sahil Malhotra, Boris Kantor, Boris Kantor, Boris Kantor   +11 more
doaj   +1 more source

A comparison of commercial light-emitting diode baited suction traps for surveillance of Culicoides in northern Europe

Parasites & Vectors, 2015
Background The response of Culicoides biting midges (Diptera: Ceratopogonidae) to artificial light sources has led to the use of light-suction traps in surveillance programmes.
Andrew Hope, Simon Gubbins, Christopher Sanders, Eric Denison, James Barber, Francesca Stubbins, Matthew Baylis, Simon Carpenter   +7 more
doaj   +1 more source

Dual monoclonal antibody-based sandwich ELISA for detection of in vitro packaged Ebola virus

Diagnostic Pathology, 2018
Background Rapid transmission and high mortality of Ebola virus disease (EVD) highlight a urgent need of large scale, convenient and effective measure for Ebola virus screening. Application of monoclonal antibodies (mAbs) are crucial for establishment of
Junjie Zai, Kai Yi, Lilan Xie, Jiping Zhu, Xiaoting Feng, Yaoming Li   +5 more
doaj   +1 more source

Emerging and re-emerging zoonotic viral diseases in Southeast Asia: One Health challenge

Frontiers in Public Health, 2023
The ongoing significant social, environmental, and economic changes in Southeast Asia (SEA) make the region highly vulnerable to the emergence and re-emergence of zoonotic viral diseases.
Paola Mariela Saba Villarroel, Paola Mariela Saba Villarroel, Nuttamonpat Gumpangseth, Nuttamonpat Gumpangseth, Thanaphon Songhong, Thanaphon Songhong, Sakda Yainoy, Arnaud Monteil, Arnaud Monteil, Pornsawan Leaungwutiwong, Dorothée Missé, Sineewanlaya Wichit, Sineewanlaya Wichit   +12 more
doaj   +1 more source