Results 191 to 200 of about 2,747,170 (398)

Engineering CRISPR System‐Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy

open access: yesAdvanced Materials, EarlyView.
This study develops a multifunctional CRISPR‐dCas9‐based OMV platform termed OMV‐C9I12, which facilitates the coexpression of CXCL9 and IL‐12 within tumor cells. This platform enhances T cell recruitment and activation, synergizes with anti‐PD‐1/PD‐L1 immunotherapy, and amplifies antitumor T cell immunity.
Hongjin Wang   +22 more
wiley   +1 more source

Development of viral vectors and application for viral entry mechanisms?

open access: yesUirusu, 2011
Virus is identified as one of the obligate intracellular parasites, which only amplify in cells of specific living things. Viral vectors, which are developed by utilizing these properties, are available in the various fields such as basic research of medical biology or application of gene therapy.
openaire   +4 more sources

Several Log Increase in Therapeutic Transgene Delivery by Distinct Adeno-Associated Viral Serotype Vectors [PDF]

open access: hybrid, 2000
Hengjun Chao   +5 more
openalex   +1 more source

The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing

open access: yesAdvanced Materials, EarlyView.
With the growing demand for cell‐based therapies, efficient cellular engineering is crucial. This review calls for greater recognition of mechanobiology principles applied through advanced biomaterial designs, mechanical confinement, and highlights recent advances using micro/nanotechnologies to enhance cell manufacturing.
Huan Ting Ong   +8 more
wiley   +1 more source

The Role of Artificial Intelligence in Advancing Biosensor Technology: Past, Present, and Future Perspectives

open access: yesAdvanced Materials, EarlyView.
This review explores the transformative role of AI in biosensor technology and provides a holistic interdisciplinary perspective that covers a broader scope of AI‐enabled biosensor technologies across various sectors including healthcare, environmental monitoring, food safety, and agriculture. It also highlights the important role of novel materials in
Tuğba Akkaş   +4 more
wiley   +1 more source

Novel Viral Vectors for Gene Therapy

open access: yesViruses
Viral vectors are gene transfer tools assembled from the backbones of naturally occurring viruses [...]
Ottmar Herchenröder   +1 more
openaire   +3 more sources

Characterization of Promoter Function and Cell-Type-Specific Expression from Viral Vectors in the Nervous System [PDF]

open access: green, 2000
R. L. Smith   +5 more
openalex   +1 more source

Interaction of Oligonucleotides with Gold Nanoparticles: Factors Beyond Electrostatic and Van‐Der Waals Forces

open access: yesAdvanced Materials Interfaces, EarlyView.
The formation of stable clusters of gold nanoparticles with oligonucleotides at different solution conditions is explored. DNA base homogeneity and strand directionality influence the binding with gold nanoparticles leading to interesting clustering behavior that can be relevant for SERS applications.
Shaila Thakur   +3 more
wiley   +1 more source

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