Results 221 to 230 of about 2,747,170 (398)

Multivariate Screening and Automated Clustering of Macrophage Immunoreactome to Nanoparticles and Photothermal Therapy

Advanced Science, EarlyView.
Predicting immune responses to treatments, including nanomedicines, with high throughput test is challenging due to the immunoreactome's complexity and plasticity. A predictive screening platform integrating pathway activation and gene profiling in macrophages has been developed as a versatile tool for designing effective immunotherapies.
Sonia Becharef, Léa Jabbour, Nassima Bekaddour, Giulio Avveduto, Nathalie Luciani, Gautier Laurent, Rana Bazzi, Edouard Alphandery, Stéphane Roux, Amanda K. A. Silva, Kelly Aubertin, Jean‐Philippe Herbeuval, Florence Gazeau   +12 more
wiley   +1 more source

Gene therapy and viral vectors. Herpes Simplex Virus as a Vector for Gene Therapy.

, 1997
Shin‐Ichi Miyatake
openalex   +2 more sources

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Viral Vectors

, 2009
Danher Wang, John Y. Dong, David H. Holman, Jan Woraratanadharm   +3 more
openaire   +2 more sources

Molecular detection of Crimean-Congo Hemorrhagic Fever (CCHF) Virus in tick species collected from livestock in Marvdasht, Fars province during 2012-2013

Armaghane Danesh Bimonthly Journal, 2015
Background & aim: Crimean–Congo hemorrhagic fever (CCHF) is a potentially lethal systemic viral disease in human beings, which is transmitted by tick bites.
F Farhadpour, Z Telmadarraiy, S Chinikar, K Akbarzadeh, MR Fakoorziba, Mj MoemenbellahFard   +5 more
doaj  

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model [PDF]

, 2001
Alberto Auricchio
openalex   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Past, Present, and Future of Viral Vector Vaccine Platforms: A Comprehensive Review. [PDF]

Vaccines (Basel)
Tang J, Amin MA, Campian JL.
europepmc   +1 more source

An investigation of excipients for a stable Orf viral vector formulation. [PDF]

Virus Res, 2023
Eilts F, Harsy YMJ, Lothert K, Pagallies F, Amann R, Wolff MW.   +5 more
europepmc   +1 more source