Results 231 to 240 of about 2,747,170 (398)

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA [PDF]

, 2001
Amit C. Nathwani, Andrew M. Davidoff, Hideki Hanawa, Junfang Zhou, Elio F. Vanin, Arthur W. Nienhuis   +5 more
openalex   +1 more source

Neutralizing Antibodies: Role in Immune Response and Viral Vector Based Gene Therapy. [PDF]

Int J Mol Sci
Tsaregorodtseva TS, Gubaidullina AA, Kayumova BR, Shaimardanova AA, Issa SS, Solovyeva VV, Sufianov AA, Sufianova GZ, Rizvanov AA.   +8 more
europepmc   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Modified HIV-1 Based Lentiviral Vectors Have an Effect on Viral Transduction Efficiency and Gene Expression in Vitro and in Vivo [PDF]

, 2001
Frank Park, Mark A. Kay
openalex   +1 more source

Viral vector-based transient expression systems for plant biotechnology research at PUIs. [PDF]

Front Educ (Lausanne)
Wang K, Hall K, Tackett K, Jordan H, Hall G, Campbell P.   +5 more
europepmc   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Fibronectin Fragment CH-296 Inhibits Apoptosis and Enhances ex Vivo Gene Transfer by Murine Retrovirus and Human Lentivirus Vectors Independent of Viral Tropism in Nonhuman Primate CD34+ Cells [PDF]

, 2001
Robert E. Donahue, Brian P. Sorrentino, Robert G. Hawley, Dong Sung An, Irvin S. Y. Chen, Robert P. Wersto   +5 more
openalex   +1 more source

Research advances in replication-deficient viral vector vaccines. [PDF]

Front Vet Sci
Wang J, Cui J, Li G, Yu L.
europepmc   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source