Results 301 to 310 of about 2,747,170 (398)

Cold-adapted influenza viruses as a promising platform for viral-vector vaccines

Expert Review of Vaccines, 2016
I. Isakova-Sivak, Tatiana S. Tretiak, L. Rudenko   +2 more
semanticscholar   +1 more source

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

Advanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang, Linyu Han, Yanfei Huo, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang   +6 more
wiley   +1 more source

Thrombotic Microangiopathy as an Emerging Complication of Viral Vector-Based Gene Therapy. [PDF]

Kidney Int Rep
Schwotzer N, El Sissy C, Desguerre I, Frémeaux-Bacchi V, Servais L, Fakhouri F.   +5 more
europepmc   +1 more source

An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non‐heading Chinese Cabbage

Advanced Science, EarlyView.
CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren   +10 more
wiley   +1 more source

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Advanced Science, EarlyView.
Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin   +10 more
wiley   +1 more source

Comparison of the Efficiency and Safety of Non-viral Vector-Mediated Gene Transfer into a Wide Range of Human Cells.

, 2002
Eriko Uchida, Hiroyuki Mizuguchi, Akiko Ishii‐Watabe, Takao Hayakawa   +3 more
openalex   +2 more sources

Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery. [PDF]

Neuroimage Rep
Poceviciute R, Mitchell K, Nikolakopoulou AM, Cho SK, Ma X, Chen P, Figueroa S, Sarmiento EJ, Singh A, Hartstein O, Loudon WG, Cros F, Kiselyov AS.   +12 more
europepmc   +1 more source

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

Robust Recall and Long-Term Memory T-Cell Responses Induced by Prime-Boost Regimens with Heterologous Live Viral Vectors Expressing Human Immunodeficiency Virus Type 1 Gag and Env Proteins

, 2002
Karl Haglund, Ingrid M. Leiner, Kristen M. Kerksiek, Linda Buonocore, Eric G. Pamer, John K. Rose   +5 more
openalex   +1 more source

Viral vector- and virus-like particle-based vaccines against infectious diseases: A minireview. [PDF]

Heliyon
Henríquez R, Muñoz-Barroso I.
europepmc   +1 more source