Results 61 to 70 of about 2,747,170 (398)
Insulated Foamy Viral Vectors [PDF]
Human Gene Therapy, 2016 Retroviral vector-mediated gene therapy is promising, but genotoxicity has limited its use in the clinic. Genotoxicity is highly dependent on the retroviral vector used, and foamy viral (FV) vectors appear relatively safe. However, internal promoters may still potentially activate nearby genes.
Diana L. Browning +5 more
openaire +3 more sources
Current Streptococcus Pneumoniae Serotypes in Sverdlovsk Region in 2020–2021
Эпидемиология и вакцинопрофилактика, 2023 Relevance. Studying the spread of individual S. pneumoniae serotypes is of special epidemiologic and clinical importance. Sverdlovsk Region with the 20% proportion of community-acquired pneumonia and its proportion among the causes of mortality of up to
E. V. Bolgarova +6 more
doaj +1 more source
The antiviral RNAi response in vector and non-vector cells against orthobunya viruses [PDF]
, 2017 Background: Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and
Bausch, DG +9 more
core +5 more sources
Wolbachia versus dengue: Evolutionary forecasts. [PDF]
, 2013 A novel form of biological control is being applied to the dengue virus. The agent is the maternally transmitted bacterium Wolbachia, naturally absent from the main dengue vector, the mosquito Aedes aegypti.
Bull, James J, Turelli, Michael
core +1 more source
Novel viral vectors in infectious diseases [PDF]
Immunology, 2017 SummarySince the development of vaccinia virus as a vaccine vector in 1984, the utility of numerous viruses in vaccination strategies has been explored. In recent years, key improvements to existing vectors such as those based on adenovirus have led to significant improvements in immunogenicity and efficacy.
Ian R. Humphreys +2 more
openaire +3 more sources
Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy. [PDF]
, 2017 Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme ...
Castanotto, Daniela +4 more
core +1 more source
AAV2.7m8 is a powerful viral vector for inner ear gene therapy
Nature Communications, 2019 Adeno-associated virus (AAV) has been successfully used to deliver gene therapy to improve auditory function in mouse models of hereditary hearing loss.
Kevin T. Isgrig +5 more
semanticscholar +1 more source
Translational Oncology, 2016 Therapeutic strategies that act by eliciting and enhancing antitumor immunity have been clinically validated as an effective treatment modality but may benefit from the induction of both cell death and immune activation as primary stimuli.
João Paulo Portela Catani +8 more
doaj +1 more source
Genome editing technologies to fight infectious diseases [PDF]
, 2017 Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa +2 more
core +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source