Results 71 to 80 of about 1,978,611 (289)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
, 2016 In Vietnam, a soldier\u27s live is saved on point by his heroic dog. Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L.
Harritan, Randy
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Social formation of colonial Virginia (1607-1680s)
Studia Humanitatis, 2018 In this article the author marks the main stages of the formation of colonial Virginia society. Its social evolution was a painful development. The traditional English social hierarchy, which the leaders of the Virginia Company tried to replicate, failed
Vostrikov Pavel Vyacheslavovich
doaj
Breaking Barriers, Building Bridges
Virginia Libraries, 2017 In this letter to colleagues working in Virginia Libraries, Keith Weimer, President of Virginia Libraries Association (VLA), 2017, discusses the year’s events and highlights.
Keith Weimer
doaj +1 more source
Crispy Critters and Earning Your Stripes [PDF]
, 2016 A sergeant in Vietnam leads his squad to recover the bodies from a downed chopper. Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in
Tedder, Steve
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Texas A&M Journal of Property Law, 2020 This Article addresses developments in Virginia oil and gas law for the period from July 31, 2014 to July 31, 2019. This period is longer than normally addressed by this journal to capture important developments in the law between this update and the last Virginia update published in 2015. At the state level, in Swords Creek Land Partnership v. Belcher,
openaire +4 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
, 2018 A Vietnam vet waits for another soldier in his therapy group to open up. Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L.
Meier, Larry
core +1 more source