Development of learning objectives to support undergraduate virology curriculum guidelines [PDF]
It has become increasingly important for microbiology educators to help students learn critical concepts of the discipline. This is particularly true in virology, where current challenges include increasing rates of vaccine hesitancy, misinformation ...
David B. Kushner+6 more
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China in December 2019 and caused a global pandemic resulting in millions of deaths and tens of millions of patients positive tests.
Tiana M. Scott+6 more
doaj +1 more source
'Trojan horses', 'logic bombs', 'armoured viruses' and 'cryptovirology' are terms recalling war gears. In fact, concepts of attack and defence drive the world of computer virology, which looks like a war universe in an information society. This war has several shapes, from invasions of a network by worms, to military and industrial espionage ...
arxiv +1 more source
A dynamic Bayesian nonlinear mixed-effects model of HIV response incorporating medication adherence, drug resistance and covariates [PDF]
HIV dynamic studies have contributed significantly to the understanding of HIV pathogenesis and antiviral treatment strategies for AIDS patients. Establishing the relationship of virologic responses with clinical factors and covariates during long-term antiretroviral (ARV) therapy is important to the development of effective treatments.
arxiv +1 more source
Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools
Virus-host interactions have received much attention in virology. Virus-virus interactions can occur when >1 virus infects a host and can be deemed social when one virus affects the fitness of another virus, as in the well-known case of superinfection ...
Samuel L. Díaz-Muñoz
doaj +1 more source
Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study [PDF]
A virologic marker, the number of HIV RNA copies or viral load, is currently used to evaluate antiretroviral (ARV) therapies in AIDS clinical trials. This marker can be used to assess the ARV potency of therapies, but is easily affected by drug exposures, drug resistance and other factors during the long-term treatment evaluation process.
arxiv +1 more source
Old Enemy with a New Face: Re-emerging Monkeypox Disease – An Update
Human monkeypox (MPX), a multi-country re-emerging disease, is rapidly spreading around the world. The etiological agent of this disease, Monkeypox virus (MPXV), is a DNA virus classified into three genetic types (West Africa, Congo Basin clade, and one ...
Md. Aminul Islam+5 more
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Varicella Vaccine: a Molecular Variant That May Contribute to Attenuation
Varicella was troublesome when varicella vaccine (vOka) was licensed in the United States. Varicella’s yearly death toll was ~100, indirect costs were massive, and varicella threatened immunocompromised children.
Anne A. Gershon, Michael D. Gershon
doaj +1 more source
A pharmacokinetic -- viral kinetic model describes the effect of alisporivir monotherapy or in combination with peg-IFN on 2 hepatitis C virologic response [PDF]
Alisporivir is a cyclophilin inhibitor with demonstrated in vitro and in vivo activity against hepatitis C 11 virus (HCV). We estimated antiviral effectiveness of alisporivir alone or in combination with 12 pegylated-Inteferon (peg-IFN) in 88 patients infected with different HCV genotypes treated for four 13 weeks.
arxiv +1 more source
Identification of a Novel Deltavirus in Boa Constrictors
Hepatitis D virus (HDV) forms the genus Deltavirus unassigned to any virus family. HDV is a satellite virus and needs hepatitis B virus (HBV) to make infectious particles.
Udo Hetzel+6 more
doaj +1 more source