Results 131 to 140 of about 17,431 (301)

Oncolytic herpes simplex virus propagates tertiary lymphoid structure formation via CXCL10/CXCR3 to boost antitumor immunity

Cell Proliferation, Volume 58, Issue 1, January 2025.
Schematic diagram illustrating the induction of TLS using oHSV to boost immunotherapy. oHSV induces TLS formation and activate the immune system. oHSV‐mediated TLS formation upregulates CXCL10/CXCR3 pathway to recruit stem‐like CD8+ T cells and enhance immune checkpoint blockade response.
Meng‐Jie Zhang, Wen‐Ping Lin, Qing Wang, Shuo Wang, An Song, Yuan‐Yuan Wang, Hao Li, Zhi‐Jun Sun   +7 more
wiley   +1 more source

Armed oncolytic viruses: A kick-start for anti-tumor immunity [PDF]

, 2018
Oncolytic viruses (OVs), viruses that specifically result in killing tumor cells, represent a promising class of cancer therapy. Recently, the focus in the OV therapy field has shifted from their direct oncolytic effect to their immune stimulatory effect.
Fouchier, R.A.M. (Ron), Graaf, J.F. de, Hoogen, B.G. (Bernadette) van den, Vor, L. (Lisanne) de   +3 more
core   +2 more sources

Advancements and challenges in brain cancer therapeutics

Exploration, Volume 4, Issue 6, December 2024.
The review summarizes various treatment options for brain tumors, focusing on their mechanisms, potential side effects, and recent developments. It emphasizes the need for personalized, multi‐modal treatment approaches in this rapidly evolving field, balancing efficacy and patient safety.
Fan Bai, Yueyang Deng, Long Li, Ming Lv, Jamoliddin Razzokov, Qingnan Xu, Zhen Xu, Zhaowei Chen, Guojun Chen, Zhitong Chen   +9 more
wiley   +1 more source

Oncolytic Virotherapy Trials—Letter [PDF]

Clinical Cancer Research, 2013
We would like to thank Prof. Harrington for his insightful commentary ([1][1]) regarding our article by Kanerva and colleagues ([2][2]). During 2007–2011, the Advanced Therapy Access Program (ATAP) provided a unique opportunity for patients to access a technology they would not otherwise have ...
Akseli Hemminki, Minna Oksanen, Maiju Merisalo-Soikkeli   +2 more
openaire   +3 more sources

Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy

Molecular Cancer, 2020
As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for conditional-replication within carcinoma cells leading to cell death via
Bin Zhang, P. Cheng
semanticscholar   +1 more source

Lung cancer and oncolytic virotherapy——enemy's enemy

Translational Oncology, 2023
Lung cancer is one of the malignant tumors that seriously threaten human health worldwide, while the covid-19 virus has become people's nightmare after the coronavirus pandemic. There are too many similarities between cancer cells and viruses, one of the
Zhang Li, Zhang Feiyue, Li Gaofeng, Liang Haifeng   +3 more
doaj  

Bioinspired micro‐ and nanostructured systems for cancer therapy

MedComm, Volume 5, Issue 12, December 2024.
Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers have employed bioengineering, bioconjugation, and micro‐ or nanotechnology to fabricate bioinspired micro‐ and nanostructured
Rui Yang, Bing Zhang, Xiawei Fei, Shanshan Cong, Shaojie Zhao, Tao Zhou, Yanting Shen   +6 more
wiley   +1 more source

Gene and virotherapy for hematological malignancies [PDF]

International Journal of Hematology, 2016
Recent years have seen a transformation in the treatment of hematological malignancies. Advances in gene therapy and molecular techniques and significant gains in computational abilities have supported the rapid development of safer and better tolerated therapies for many patients with hematologic cancers.
Masato Yamamoto, Evidio Domingo-Musibay
openaire   +3 more sources

Oncolytic Viruses and the Immune System: The Dynamic Duo

Molecular Therapy: Methods & Clinical Development, 2020
Oncolytic viruses (OVs) constitute a new and promising immunotherapeutic approach toward cancer treatment. This therapy takes advantage of the natural propensity of most tumor cells to be infected by specific OVs.
Ana Lemos de Matos, Lina S. Franco, Grant McFadden   +2 more
doaj  

Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer [PDF]

, 2016
BACKGROUND: A major hurdle incurrent to the human clinical application of conditionally replicative adenovirus (CRAd)-based virotherapy agents is their limited therapeutic efficacy.
Ashshi, Ahmad Mohammad, Curiel, David T, Dmitriev, Igor P, El-Shemi, Adel Galal, Kashentseva, Elena A   +4 more
core   +2 more sources