Results 241 to 250 of about 59,693 (314)

Molecular LEGION: incalculably large coverage of chemical space around the NLRP3 target. [PDF]

Sci Data
Zagribelnyy B, Aladinskiy V, Bondarev N, Ilin I, Malkov M, Vasileva A, Ding X, Lin A, Shayakhmetov R, Aliper A, Ren F, Zhavoronkov A.   +11 more
europepmc   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source

Standardized RNA extraction protocol for <i>Entamoeba</i> species: advancing molecular diagnostics and amebiasis control. [PDF]

Front Cell Infect Microbiol
Cox G, Melo M, Andrade A, Müller B, Dos Santos A, Moreira ADS, de Araujo NS, Moreira D, Parente T, Degrave W, Toma H, Waghabi M.   +11 more
europepmc   +1 more source

AI‐based localization of the epileptogenic zone using intracranial EEG

Epilepsia Open, EarlyView.
Abstract Artificial intelligence (AI) is rapidly transforming our lives. Machine learning (ML) enables computers to learn from data and make decisions without explicit instructions. Deep learning (DL), a subset of ML, uses multiple layers of neural networks to recognize complex patterns in large datasets through end‐to‐end learning.
Atsuro Daida, Yipeng Zhang, Sotaro Kanai, Richard Staba, Vwani Roychowdhury, Hiroki Nariai   +5 more
wiley   +1 more source

Enhanced Thompson sampling by roulette wheel selection for screening ultralarge combinatorial libraries. [PDF]

J Cheminform
Zhao H, Nittinger E, Yu MA, Gathiaka S, Walters WP, Tyrchan C.   +5 more
europepmc   +1 more source

Early Feasibility of Registration of Micro‐PET/CT Scans to Annotated 3D Specimen Models

Head &Neck, EarlyView.
ABSTRACT Background Intraoperative 18F‐fluorodeoxyglucose (18F‐FDG) micro‐positron emission tomography/computed tomography (micro‐PET/CT) is an emerging modality for margin assessment. Prior to clinical use, micro‐PET/CT margin distances must be correlated with gold‐standard histopathology.
Joaquin Austerlitz, Andreja Radevic, Ashtyn McAdoo, Kyrionna Golliday, Cheng Ye, Daniel Fabbri, Adam J. Rosenberg, Marcus Balanky, Anas Alabkaa, Kim A. Ely, Mitra Mehrad, Spencer Roark, Eben Rosenthal, Michael C. Topf   +13 more
wiley   +1 more source

The Selectivity Implications of Docking Libraries with Greater and Lesser Similarities to Bio-like Molecules. [PDF]

J Med Chem
Hall BW, Sakamoto K, Huang XP, Irwin JJ, Shoichet BK, Roth BL.   +5 more
europepmc   +1 more source

Providing Mental Health and Substance Use Services to People Released From Custody During the COVID‐19 Pandemic: A Qualitative Study of Service Providers

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT This paper explores the perspectives of mental health and substance use providers who supported people released from custody during the pandemic in Ontario, Canada, with a focus on service disruptions, adaptations, and experiences. We conducted 20 in‐depth qualitative interviews and analysed these using Applied Thematic Analysis.
Lucas M. Seuren, Arthur McLuhan, Madison Ford, Nikoleta Curcin, Angela Mashford‐Pringle, Patricia O'Campo, Flora I. Matheson   +6 more
wiley   +1 more source

Artificial intelligence in drug research and development: a review of methods and applications in drug repurposing. [PDF]

Brief Bioinform
Zielińska A, Fornalik M, Szczepaniak M, Gimla M, Lemańska A, Cielecka-Piontek J, Souto EB.   +6 more
europepmc   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source