Results 71 to 80 of about 1,353,740 (313)

Inhibitors of Helicobacter pylori protease HtrA found by "virtual ligand" screening combat bacterial invasion of epithelia

, 2011
Background: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention.
Löwer, Martin, Schneider, Gisbert, Petra Schneider, Hoy Benjamin, Löwer Martin, Martin Löwer, Tim Geppert, Geppert, Tim, Silja Wessler, Wessler Silja, Schneider, Petra, Geppert Tim, Gisbert Schneider, Benjamin Hoy, Hoy, Benjamin, Weßler, Silja, Schneider Petra, Schneider, Gisbert (Prof. Dr.), Schneider Gisbert   +18 more
core   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Las bibliotecas virtuales en Alemania. Conexiones entre el saber, la información y la técnica

Anales de Documentación, 2001
Como resumen de una conferencia dada en Colonia para bibliotecarios españoles y latinoamericanos, la autora explica iniciativas recientes de bibliotecas virtuales y digitales en Alemania.
Regine Schmolling
doaj  

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Oman Virtual Science Library – Masader

, 2023
This Poster will give a brief about Oman Library E-Resources consortium called: "Oman Virtual Science Library-Masader. Masader is the brand name of the Oman Virtual Science Library, which provides seamless and affordable access to a wealth of global ...
Alaraimi, Hisham, Albattashi, Muneer, Albadi, Waleed   +2 more
core   +1 more source

Design and Implementation of Iraqi Virtual Library

Al-Khawarizmi Engineering Journal, 2010
In developing countries, individual students and researchers are not able to afford the high price of the subscription to the international publishers, like JSTOR, ELSEVIER,…; therefore the governments and/or universities of those countries aim to ...
Jalal B. Raouf, Mohammed Najm Abdulla, Bahaa I. Kazem   +2 more
doaj  

A Grid Services Implementation for a Virtual Research Environment

, 2005
In the past, virtual learning and research environments have typically been implemented as monolithic systems. Current research focuses on creating such environments from selected Grid and Web services.
Hall, W, G. Wills, W. Hall, Wills, GB, H C Davis, Grange, S, D. Millard, Davis, HC, S Grange, L. Carr, L. GILBERT, Miles-Board, T, Carr, LA, Millard, DE, Gilbert, L, Gee, Q, T Miles-Board, Q Gee   +17 more
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Virtual and Digital Libraries [PDF]

, 2006
Library operations today are entirely different from what we have experienced in the past and we can expect a tremendous change in the future. These changes may affect almost all the fields of library organization and library management.
Bhange, Chinmayee
core  

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source