scGPA: an LLM-assisted workflow for directional virtual gene perturbation analysis from single-cell transcriptomes. [PDF]
Tang H +12 more
europepmc +1 more source
Nonreciprocal Swarmalators With Reconfigurable and Controllable Formations for Robot Collectives
Nonreciprocal swarmalator interactions are enabled through control barrier functions to transform self‐organizing robot collectives into reconfigurable, constraint‐aware systems. Complex two‐ and three‐dimensional shapes, continuous morphing, obstacle‐aware navigation, collective splitting, and object transport emerge from modulating agent‐level ...
Kush Patel +3 more
wiley +1 more source
Integrated Single Cell Analysis Reveals the Transcriptional Heterogeneity of Mouse Double Negative T Cells. [PDF]
Zhao J, Zhu J, Zhang J.
europepmc +1 more source
Consensus Formation and Change are Enhanced by Neutrality
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag +3 more
wiley +1 more source
Virtual patients in medical education: a bibliometric analysis based on the wos core collection and scopus databases. [PDF]
Ye Y +7 more
europepmc +1 more source
Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu +7 more
wiley +1 more source
Virtual reality in neurorehabilitation for musculoskeletal disorders: a bibliometric analysis from 2010 to 2025. [PDF]
Zhang L +5 more
europepmc +1 more source
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen +7 more
wiley +1 more source
Drug Design Studio (DDS) 2.0: A Unified Platform for Network Pharmacology Integrated with Docking and Virtual Screening Workflow for Covalent/Non-Covalent Binders. [PDF]
Soliman ME.
europepmc +1 more source
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source

