Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
NetworkGuard: An Edge-Based Virtual Network Sensing Architecture for Real-Time Security Monitoring in Smart Home Environments. [PDF]
Sensors (Basel)El Khaled D +3 more
europepmc +1 more source
Cloud Network Function Virtualization (NFV)
International Journal For Multidisciplinary ResearchCloud Network Function Virtualization (NFV) is a groundbreaking technology that revolutionizes the way network services are delivered. By virtualizing network functions, NFV enables faster deployment, scalability, and management of network services. This article explores the benefits and use cases of NFV, including virtualized load balancers, firewalls,
openaire +1 more source
Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface
Advanced Science, EarlyView.Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley +1 more source
Artificial intelligence-enabled multi-scale virtual cell: perspective, challenges, and opportunities. [PDF]
Brief BioinformJiang H +8 more
europepmc +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Assessment of basketball players' motion quality degradation by video-based virtual sensing and the AGCN-Mamba network. [PDF]
BMC Sports Sci Med RehabilYang Z, Zhao Y.
europepmc +1 more source
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Effects of exercise regimens on balance ability in older patients with osteoporosis: a systematic review and Bayesian network meta-analysis of randomized controlled trials. [PDF]
Front PhysiolLiu X +7 more
europepmc +1 more source
Spintronic Bayesian Hardware Driven by Stochastic Magnetic Domain Wall Dynamics
Advanced Science, EarlyView.Magnetic Probabilistic Computing (MPC) utilizes intrinsic stochastic dynamics in domain walls to establish a hardware foundation for uncertainty‐aware artificial intelligence. Thermally driven domain‐wall fluctuations, voltage‐controlled magnetic anisotropy, and TMR readout enable fully electrical, tunable probabilistic inference.
Tianyi Wang +11 more
wiley +1 more source