Results 181 to 190 of about 8,191,958 (327)

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Total Focusing in the Virtual Wave Domain: 3D Defect Reconstruction Using Spatially Structured Laser Heating

TOTAL FOCUSING IN THE VIRTUAL WAVE DOMAIN: 3D DEFECT RECONSTRUCTION USING SPATIALLY STRUCTURED LASER HEATING Total Focusing in the Virtual Wave Domain: 3D Defect Reconstruction Using Spatially Structured Laser Heating / Lecompagnon, Julien (Rights ...
Hassenstein, Christian, Rooch, Ludwig, Lecompagnon, Julien, Ziegler, Mathias, Inoue, H., Sakagami, T.   +5 more
core  

Molecular Rectification: Mechanisms, Modulation Strategies, and Device Realization

Advanced Science, EarlyView.
This review focuses on molecular rectification, from its fundamental mechanisms and modulation strategies to device realization. It summarizes the theoretical framework, modulation strategies, fabrication techniques, characterization methods, and modeling and simulation of molecular rectifiers, while discussing challenges and future directions for ...
Junnan Guo, Shufan Song, Wenhui Fang, Jifeng Tang, Wenhao Li, Weikang Wu, Shishen Yan, Hui Li, Lishu Zhang   +8 more
wiley   +1 more source

¿Cómo se aprende una asignatura en la modalidad Virtual?

, 2015
El vídeo describe la metodología a seguir en cada una de las asignaturas en la modalidad ...
UC Virtual
core  

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Data‐Driven and Physics‐Informed Modeling Perspectives for Soft Manipulators: From SINDy to Hybrid Intelligence

Advanced Science, EarlyView.
This Perspective charts the modeling landscape for soft manipulators, spanning sparse system identification, neural dynamics, physics‐informed models and hybrid intelligence. We examine how physics, data, sensing, adaptation and control can assume complementary roles within this landscape, and provide a framework for selecting modeling approaches ...
Wenbo Hui, Yunyi Wang, Teng Zhang, Yang Chen, Min Pan   +4 more
wiley   +1 more source

Basics of Theoretical Foundations in Historic Experimental Studies in the Sense of Practicability

EXARC Journal
Researchers working in historical disciplines (history, archaeology, art history, legal history, theology) can draw on a source base that has grown in varying degrees.
Boris Dreyer
doaj  

Virtual reconstruction and analysis of the face of DFN3-150 Paradolichopithecus aff. arvernensis specimen from Dafnero, Greece. [PDF]

Sci Rep
Koutalis S, Röding C, Merceron G, Guy F, Kostopoulos DS, Harvati K.   +5 more
europepmc   +1 more source

µSlicer for Programmable Multimaterial 3D Printing

Advanced Science, EarlyView.
ABSTRACT Nature rarely builds with uniform materials; instead, it achieves exceptional performance by arranging composition and structure across multiple length scales. Mimicking such architectures has become increasingly feasible with additive manufacturing, and especially with multimaterial 3D printing, where complex structures with spatially varying
Daniel H. Meile, Berin Šeta, Md. Tusher Mollah, Yohan Jacquet, Rob Wolfs, Jon Spangenberg   +5 more
wiley   +1 more source

Validation of the Posture Analyzing and Virtual Reconstruction (PAViR) System for Measuring the Hip-Knee-Ankle Angle Using 2D Photogrammetry and Computer Vision. [PDF]

Diagnostics (Basel)
Aguilar Esteban C, Martinez Mendoza E, Martinez Navarro C, Torralba Estelles J.   +3 more
europepmc   +1 more source