Results 211 to 220 of about 2,795,372 (389)

Ultrafast Radiative Recombination Engineering in InGaN/GaN Quantum Wells through Temperature, Alloy Fraction and Layer's Width Tuning for Photonics

Advanced Theory and Simulations, EarlyView.
A side‐view schematic illustrating intra‐ and inter‐band optical recombination processes in quantum wells, highlighting applications that depend on carrier dynamics and recombination lifetimes, such as lasers, photodetectors, and solar cells. Abstract Radiative lifetime (RT) on the picosecond to femtosecond scale plays a key role in enabling ultrafast ...
Redouane En‐nadir
wiley   +1 more source

Sequence-based virtual screening using transformers. [PDF]

Nat Commun
Zhang S, Huo D, Horne RI, Qi Y, Pujalte Ojeda S, Yan A, Vendruscolo M.   +6 more
europepmc   +1 more source

Ligand-Based Virtual Screening to Identify New T-Type Calcium Channel Blockers [PDF]

, 2007
Ismaïl Ijjaali, Christian Barrère, Joël Nargeot, François Petitet, Emmanuel Bourinet   +4 more
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Screening virtual basado en topología molecular: una nueva metodología en el descubrimiento de agentes anticonvulsivos [PDF]

, 2007
Alan Talevi
openalex   +1 more source

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease

Life Science, 2020
Mahmoud Kandeel, M. Al-Nazawi
semanticscholar   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Ultrahigh-Throughput Virtual Screening Strategies against PPI Targets: A Case Study of STAT Inhibitors. [PDF]

J Chem Inf Model
Szalai TV, Péczka N, Sipos-Szabó L, Petri L, Bajusz D, Keserű GM.   +5 more
europepmc   +1 more source

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Advanced Science, EarlyView.
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu, Pengling Wei, Lirong Chen, Ling Gao, Xiaole Xia   +4 more
wiley   +1 more source

Discovery of Small Molecules Targeting Norovirus 3CL Protease by Multi-Stage Virtual Screening. [PDF]

Int J Mol Sci
Shi Z, Liu N, Zhao F, Kang D, De Jonghe S, Neyts J, Gao N, Liu X.   +7 more
europepmc   +1 more source