Results 41 to 50 of about 1,287,942 (312)

You Are Only as Good as You Are Behind Closed Doors: The Stability of Virtuous Dispositions [PDF]

, 2020
Virtues are standardly characterized as stable dispositions. A stable disposition implies that the virtuous actor must be disposed to act well in any domain required of them. For example, a politician is not virtuous if s/he is friendly in debate with an
Goldstein, Rena Beatrice
core  

Emotion, deliberation, and the skill model of virtuous agency [PDF]

, 2018
A recent skeptical challenge denies deliberation is essential to virtuous agency: what looks like genuine deliberation is just a post hoc rationalization of a decision already made by automatic mechanisms (Haidt 2001; Doris 2015).
Annas, Annas, Arango-Muñoz, Arpaly, Avery, Barlow, Bloomfield, Brader, Brink, Brownstein, Chambon, Christensen, Corr, Csikszentmihalyi, Davis, Doris, Dreyfus, Endler, Enoch, Foot, Frankfurt, Gray, Haggard, Haidt, Herman, Hookway, Jacobson, Kennett, Klein, Korsgaard, Kurth, Kurth, Kurth, Kurth, Leary, Levenson, Lewis, MacKuen, Marks, Mathews, McDowell, Mercer, Mor, Murphy, Nagel, Oppenheimer, Perkins, Pizarro, Price, Proust, Railton, Railton, Rawls, Sauer, Slote, Sperber, Stanley, Stichter, Stohr, Sutton, Thompson, Tiberius, Valentino, Velleman, Watson, Wolf, Öhman   +66 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Moral Education in the Perspective of Liberal Education, Natural Law and the Modern Doctrine of Social Contract

Paedagogia Christiana, 2020
Wychowanie moralne w perspektywie kształcenia ogólnego, prawa naturalnego i koncepcji umowy społecznejArtykuł zawiera analizę relacji między pojęciami kształcenia ogólnego, wychowania moralnego oraz prawa naturalnego.
Jan Rutkowski
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Plato, Identity, and Virtue [PDF]

Metaphysics, 2016
A common understanding of identity is a logical principle with the formula A is A. In this understanding, identity is a principle which lacks dimension, and epistemic and existential meaning; therefore, with regard to this principle, nothing can be ...
Naser Momeni, Reza Davari Ardakani
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Combining methylated RNF180 and SFRP2 plasma biomarkers for noninvasive diagnosis of gastric cancer

Translational Oncology
Introduction: Gastric cancer (GC) is a common malignant tumor, and early diagnosis significantly improves patient survival rates. This study aimed to investigate the diagnostic value of ring finger protein 180 (RNF180) and secreted frizzled protein 2 ...
Zhihao Dai, Jin Jiang, Qianping Chen, Minghua Bai, Quanquan Sun, Yanru Feng, Dong Liu, Dong Wang, Tong Zhang, Liang Han, Litheng Ng, Jun Zheng, Hao Zou, Wei Mao, Ji Zhu   +14 more
doaj   +1 more source

Meno: Virtue as οὐσία and εἶδος

Problemos, 2022
The article is an interpretation of the first part of the Meno (70a-79e), in which Plato deals with the problem of knowledge of virtue. Parmenides’ being, constituted by Justice, becomes a reference point for reflecting on the ontological and cognitive ...
Skirmantas Jankauskas
doaj   +1 more source

Forgiveness Or Fairness? [PDF]

, 2015
Several philosophers who argue that forgiveness is an important virtue also wish to maintain the moral value of retributive emotions that forgiveness is meant to overcome.
Thomason, Krista Karbowski
core   +2 more sources