Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains [PDF]
, 2013 BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks
Bull, TJ +7 more
core +1 more source
Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System
Advanced Science, EarlyView.Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei +7 more
wiley +1 more source
Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2‐Deoxyglucose
Angewandte Chemie, EarlyView.New approaches to combat antimicrobial‐resistant pathogens are needed. Here, scaffolding a nonmetabolizable sugar (2DG) on a polymer backbone is shown to significantly improve its antimicrobial activity. ABSTRACT With the increasing prevalence of multidrug‐resistant (MDR) pathogens, last‐line therapeutics such as cyclic peptides are insufficient ...
Sungjin Jeon +4 more
wiley +2 more sources
No genetic link between E. coli isolates carrying mcr-1 in bovines and humans in France
Journal of Global Antimicrobial ResistanceBackground: Colistin is a last-line antibiotic used to treat severe human infections caused by carbapenemase-producing Gram-negative bacteria. In parallel, colistin has massively been used in the veterinary field so that mcr-1-positive E.
Marisa Haenni +6 more
doaj +1 more source
Advanced Science, EarlyView.This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao +6 more
wiley +1 more source
A food chain approach to control of Shiga toxin-producing Escherichia coli in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science at Massey University, Palmerston North, New Zealand [PDF]
, 2018 Part of Chapter 3 has been published as: Browne, A.S., Midwinter, A.C., Withers, H., Cookson, A.L., Biggs, P.J., Marshall J.C., Benschop, J., Hathaway, S., Haack, N., Akhter, R., & French, N.P. (2018).
Browne, Andrew Springer
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Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300. [PDF]
, 2012 BackgroundCommunity-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a significant bacterial pathogen that poses considerable clinical and public health challenges.
Bansal, Vikas +7 more
core +2 more sources
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Parasites & Vectors, 2017 Background Borrelia burgdorferi (sensu lato), the causative agent of Lyme borreliosis is a bacterium transmitted by hard ticks, Ixodes spp. Bacteria are injected into the host skin during the tick blood meal with tick saliva.
Quentin Bernard +3 more
doaj +1 more source
Distribution and conservation of Banana Streak Virus (BSV) within banana Musa balbisiana genome: what impact on host and virus evolution ? [PDF]
, 2011 The nuclear genome of several plants isinvaded by numerous viral sequences. These integrations correspond to accidental events mainly resulting from illegitimate recombination of DNA viruses belonging to the family Caulimoviridae with plant DNA whereas ...
Chabannes, Matthieu +4 more
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