Results 111 to 120 of about 532,349 (305)

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Successful implementation of infection control measure in a neonatal intensive care unit to combat the spread of pathogenic multidrug resistant Staphylococcus capitis

Antimicrobial Resistance and Infection Control, 2019
Background Once present in a neonatal intensive care unit (NICU), multidrug resistant Staphylococcus capitis NRCS-A is able to settle and diffuse. Objective The objective of this study was to evaluate the impact of infection control (IC) interventions to
Jérôme Ory, Michel Cazaban, Brigitte Richaud-Morel, Massimo Di Maio, Catherine Dunyach-Remy, Alix Pantel, Albert Sotto, Frédéric Laurent, Jean-Philippe Lavigne, Marine Butin   +9 more
doaj   +1 more source

Virulence-associated genes detected by genome analysis.

, 2018
Virulence-associated genes detected by genome analysis.
Estelle Jumas-Bilak (54354), Brigitte Lamy (131457), Fadua Latif-Eugenín (5635019), Roxana Beaz-Hidalgo (685156), Sophie Colston (5635022), Maria-Jose Figueras (685157), Joerg Graf (229951), Emilie Talagrand-Reboul (5467292)   +7 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Virulence-associated cell wall synthesis and transport.

, 2017
Virulence-associated cell wall synthesis and transport.
Ashutosh N. Aggarwal (358734), Shet Masih (3830167), Suman Laal (85057), Rakesh Yadav (377372), Sumedha Sharma (1746832), Indu Verma (632873), Sunil Sethi (85053), Michelle B. Ryndak (585268)   +7 more
core   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence [PDF]

, 2013
Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth and virulence, disease progression, and infection control. However, our understanding of this crucial process is still rather limited because of experimental and ...
Burton, Neil A, Mazé, Alain, Beatrice Claudi (126116), Dirk Bumann (126124), Dirk Bumann, Schmidt Alexander, Burton Neil A., Farhan Hesso, Steeb Benjamin, Claudi Beatrice, Bumann Dirk, Alexander Schmidt, Hesso Farhan, Mazé Alain, Benjamin Steeb (148560), Tienz Petra, Neil A. Burton (407008), Beatrice Claudi, Alexander Schmidt (68515), Petra Tienz, Alain Mazé, Hesso Farhan (407009), Alain Mazé (126117), Neil A Burton, Claudi, Beatrice, Petra Tienz (291552), Tienz, Petra, Farhan, Hesso, Burton, Neil A., Bumann, Dirk, Benjamin Steeb, Steeb, Benjamin, Schmidt, Alexander   +32 more
core   +2 more sources

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Characterization of Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Meat in Tunisia

Journal of Food Protection
Food-producing animals are potential reservoirs of resistance to antibiotics classified as critically important for human health, such as extended-spectrum cephalosporins (ESC) and carbapenems (CP).
Imen Hmidi, Meriem Souguir, Véronique Métayer, Antoine Drapeau, Pauline François, Jean-Yves Madec, Marisa Haenni, Wejdene Mansour   +7 more
doaj   +1 more source

Current virulence of Pyrenophora teres on barley in Western Australia [PDF]

, 2001
Studies on variation, occurrence, and distribution of virulence in Pyrenophora teres are helpful to identify effective sources of resistance that can be used for barley breeding in Western Australia.
Gupta, S., Loughman, R.
core