Results 141 to 150 of about 861,199 (358)
High host density favors greater virulence: a model of parasite-host dynamics based on multi-type branching processes [PDF]
arXiv, 2011 We use a multitype continuous time Markov branching process model to describe the dynamics of the spread of parasites of two types that can mutate into each other in a common host population. Instead of using a single virulence characteristic which is typical of most mathematical models for infectious diseases, our model uses a combination of two ...
arxiv
The Shigella flexneri OmpA amino acid residues 188EVQ190 are essential for the interaction with the virulence factor PhoN2 [PDF]
, 2016 Shigella flexneri is an intracellular pathogen that deploys an arsenal of virulence factors promoting host cell invasion, intracellular multiplication and intra- and inter-cellular dissemination.
Ambrosi, Cecilia +9 more
core +1 more source
The Complex Relationship between Virulence and Antibiotic Resistance
Genes, 2017 Antibiotic resistance, prompted by the overuse of antimicrobial agents, may arise from a variety of mechanisms, particularly horizontal gene transfer of virulence and antibiotic resistance genes, which is often facilitated by biofilm formation.
M. Schroeder, B. Brooks, A. Brooks
semanticscholar +1 more source
Novel Bivalent mRNA‐LNP Vaccine for Highly Effective Protection against Pneumonic Plague
Advanced Science, EarlyView.The study investigates mRNA‐lipid nanoparticle vaccines targeting Yersinia pestis, the causative agent of plague. Combined F1+LcrV mRNA vaccination elicited robust immune responses and protected mice against virulent wild‐type and atypical strains.
Uri Elia +12 more
wiley +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Objective To investigate mental health symptoms (anxiety, depression, and sleep status) and their associated factors among people infected with the SARS‐CoV‐2 omicron variant during the quarantine period in Shanghai. Methods To investigate the mental health symptoms among participants with SARS‐CoV‐2 omicron infection, an anonymous online ...
Zhenghua Hou +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.This study presents novel macrocyclic peptides with low nanomolar affinity for CD59, an immunomodulatory cell surface receptor associated with human disease. Crystallographic and structure‐activity relationship (SAR) studies reveal peptide CP‐06 mimics the binding of biologically relevant CD59 interaction partners. Dimeric and lipidated CP‐06 analogues
Jasmine K. Bickel +12 more
wiley +2 more sources
Back to the Origin: blaOXA-204 and blaNDM-1 Genes in Shewanella spp. from a Tunisian River
Microbiology Spectrum, 2022 Sana Ncir +8 more
doaj +1 more source
Microorganisms, 2019 Virulence plasmids are associated with hypervirulent types of Klebsiella pneumoniae, which generally do not carry antibiotic resistance genes. In contrast, nosocomial isolates are often associated with resistance, but rarely with virulence plasmids. Here,
J. Turton +5 more
semanticscholar +1 more source
Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Advanced Science, EarlyView.The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.A pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Shuaibing Zhang +7 more
wiley +2 more sources