Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
The fungal effector UvDUF1 from Ustilaginoidea virens not only promotes infection but also acts as a plant immunity elicitor, inducing broad‐spectrum disease resistance in rice and Nicotiana benthamiana. These results reveal its potential as a novel target for sustainable crop protection strategies.
Shuchen Wang +13 more
wiley +1 more source
Effects of quercetin, baicalein, azithromycin, and their combination on biofilm formation, virulence factors and gene expression associated with Pseudomonas aeruginosa quorum sensing. [PDF]
Parra Rodríguez V +3 more
europepmc +1 more source
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu +4 more
wiley +1 more source
Virulence profiling and biofilm-forming capacity of different <i>E. coli</i> pathotypes and phylogroups isolated from calf diarrhoea. [PDF]
Karahutová L +2 more
europepmc +1 more source
Smart label design. ABSTRACT The growing interest to ensure food safety requires the development of smart indicator systems that are capable of real‐time tracking of spoilage, particularly for perishable foods. Therefore, the purpose of this work is to fabricate eco‐friendly, industrially viable pH‐sensitive smart films via solvent‐free melt ...
Bedriye Ucpinar
wiley +1 more source
SSU_RS09155, a virulence-associated gene encoding a putative membrane of unknown function, that is essential for Streptococcus suis serotype 2 virulence. [PDF]
Payen S +4 more
europepmc +1 more source
Biosurfactant was produced by Pseudomonas aeruginosa using andiroba waste from Amazonia. A biosurfactant–alginate composite (Alg/BioS) was successfully synthesized via ionotropic gelation, and achieved up to 70% Cr6+ removal from water. Abstract Environmental contamination by heavy metals represents a significant challenge due to their persistence in ...
Paulo Diniz Austriaco +11 more
wiley +1 more source
Divergent transcriptomic trajectories in CD4/CD8β/TcR1 bead-enriched peripheral lymphocyte fraction following experimental infection with low- and high-virulence strains of noncytopathic bovine viral diarrhea virus type 2. [PDF]
Bauermann FV +4 more
europepmc +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source

