Results 81 to 90 of about 2,401,730 (258)

O‑Island 28 encodes a type I secretion and RTX adhesion system regulated by RstA and required for early EHEC O157:H7 adherence

Gut Microbes
Enterohemorrhagic Escherichia coli (EHEC) is a leading foodborne pathogen worldwide that causes severe diarrheal disease, hemorrhagic colitis, and hemolytic uremic syndrome, representing a significant threat to public health.
Tianshui Niu, Mengqian Huang, Fei He, Xianjuan Yu, Aifeng Chen, Yan Shi, Jiaying Han, Xiang Lian, Junwei Su, Yutao Liu, Chuhui Ru   +10 more
doaj   +1 more source

Enterococcus faecalis Enhances Expression and Activity of the Enterohemorrhagic Escherichia coli Type III Secretion System

mBio, 2019
The gut microbiota can significantly impact invading pathogens and the disease they cause; however, many of the mechanisms that dictate commensal-pathogen interactions remain unclear.
Elizabeth A. Cameron, Vanessa Sperandio, Gary M. Dunny   +2 more
doaj   +1 more source

A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum [PDF]

, 2013
Clonally variant protein expression in the malaria parasite Plasmodium falciparum generates phenotypic variability and allows isogenic populations to adapt to environmental changes encountered during blood stage infection.
Nicolas M B Brancucci, Kathrin Witmer, Kathrin Witmer (252635), Brancucci, Nicolas M. B., Schmid, Christoph, Christoph Schmid (44586), Till S. Voss (252644), Nicolas M. B. Brancucci (579187), Till S Voss, Witmer, Kathrin, Voss, Till S., Nicolas M. B. Brancucci, Till S. Voss, Christoph Schmid   +13 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

PGLYRP4 Enhances Shigella flexneri Virulence by Promoting virF Transcription via the CpxA/R Two‐Component System

MicrobiologyOpen
The human gastrointestinal tract provides a complex environment for bacterial pathogens, necessitating their adaptation to host defenses and microbiota.
Rita Trirocco, Gianni Prosseda
doaj   +1 more source

Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi [PDF]

, 2015
Virulence and host range in Rhodococcus equi depends on the variable pathogenicity island of their virulence plasmids. Notable gene products are a family of small secreted virulence-associated proteins (Vaps) that are critical to intramacrophagic ...
Blagova, Elena V., Okoko, Tebekeme, Dover, Lynn, Wilkinson, Anthony, Dover, Lynn G., Blagova, Elena, Whittingham, Jean L., Whittingham, Jean, Wilkinson, Anthony J.   +8 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus [PDF]

, 2010
Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H., G. Koch, B. P. H. Peeters, Rottier, P.J.M., Dortmans, J.C.F.M., J. C. F. M. Dortmans, P. J. M. Rottier, Koch, G.   +7 more
core   +1 more source

A Genome-Wide Association Study Identifies Genomic Regions for Virulence in the Non-Model Organism Heterobasidion annosum ss [PDF]

, 2013
The dense single nucleotide polymorphisms (SNP) panels needed for genome wide association (GWA) studies have hitherto been expensive to establish and use on non-model organisms.
Olson, Åke, Brandström Durling, Mikael, Himmelstrand, Kajsa, Dalman, Kerstin, Stenlid, Jan, Lind, Mårten   +5 more
core   +3 more sources

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

Advanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song, Yuting Wang, Zhaolun Wang, Shunji Zhang, Zhengmin Tang, Yongcheng Wang   +5 more
wiley   +1 more source