Results 101 to 110 of about 487,341 (302)

SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts

Journal of Virology
Membrane fusion occurs at the early stages of SARS-CoV-2 replication, during entry of the virus, and later during the formation of multinucleated cells called syncytia.
William Bolland, Inès Marechal, Chloé Petiot, Françoise Porrot, Florence Guivel-Benhassine, Anne Brelot, Nicoletta Casartelli, Olivier Schwartz, Julian Buchrieser   +8 more
doaj   +1 more source

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

Advanced Functional Materials, EarlyView.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao, Darine D'Adam, Anna Hu, Sixuan Zhang, Josua Roduner, Katharina Maniura‐Weber, Qun Ren   +6 more
wiley   +1 more source

Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease

Nature Communications
Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identify a replication enhancing domain (ReED) in non-structural protein 5A conferring high replication ...
Paul Rothhaar, Tomke Arand, Ha Gyu-Thomas Seong, Christian Heuss, Margaret Tulessin, Zhiqing Wang, Colin Förster, Alina C. Schneider, Jocelyn Quistrebert, Haiting Chai, Marvin Reineke, Louise Benning, Jonathan Honegger, Maike Hofmann, Robert Thimme, Jörg Timm, STOPHCV investigators, Paul Schnitzler, Uta Merle, Naglaa H. Shoukry, Julie Bruneau, Chaturaka Rodrigo, Andrew Lloyd, Rowena A. Bull, M. Azim Ansari, Carolin Mogler, John McLauchlan, Xavier Forns, Sofía Pérez-del-Pulgar, Volker Lohmann   +29 more
doaj   +1 more source

Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools

mSystems, 2019
Virus-host interactions have received much attention in virology. Virus-virus interactions can occur when >1 virus infects a host and can be deemed social when one virus affects the fitness of another virus, as in the well-known case of superinfection ...
Samuel L. Díaz-Muñoz
doaj   +1 more source

Influenza reverse genetics: dissecting immunity and pathogenesis

, 2014
Reverse genetics systems allow artificial generation of non-segmented and segmented negative-sense RNA viruses, like influenza viruses, entirely from cloned cDNA.
Evans, Justin G., Stambas, John, Ye, Siying   +2 more
core   +1 more source

Wolbachia versus dengue: Evolutionary forecasts. [PDF]

, 2013
A novel form of biological control is being applied to the dengue virus. The agent is the maternally transmitted bacterium Wolbachia, naturally absent from the main dengue vector, the mosquito Aedes aegypti.
Bull, James J, Turelli, Michael
core   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Biagio Palmisano, Silvia Franco, Roberta Angelini, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +14 more
wiley   +1 more source

Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2.

PLoS ONE, 2020
MotivationBeside socio-economic issues, coronavirus pandemic COVID-19, the infectious disease caused by the newly discovered coronavirus SARS-CoV-2, has caused a deep impact in the scientific community, that has considerably increased its effort to ...
Mercè Llabrés, Gabriel Valiente
doaj   +1 more source

Cellular expression and crystal structure of the murine cytomegalovirus MHC-Iv glycoprotein, m153 [PDF]

, 2007
Mouse cytomegalovirus (MCMV), a β-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions.
Balbo, Andrea, Eikel, Daniel, Hess, Sonja, Jonjić, Stipan, Mans, Janet, Margulies, David H., Natarajan, Kannan, Robinson, Howard, Schuck, Peter, Tiemessen, Caroline T., Šimić, Hrvoje   +10 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source