Results 41 to 50 of about 6,581,491 (250)

Virus like particles as a platform for cancer vaccine development [PDF]

PeerJ, 2017
Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines.
Hui Kian Ong, Wen Siang Tan, Kok Lian Ho
doaj   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Viruses of protozoan parasites and viral therapy: Is the time now right?

Virology Journal, 2020
Infections caused by protozoan parasites burden the world with huge costs in terms of human and animal health. Most parasitic diseases caused by protozoans are neglected, particularly those associated with poverty and tropical countries, but the paucity ...
Paul Barrow, Jean Claude Dujardin, Nicolas Fasel, Alex D. Greenwood, Klaus Osterrieder, George Lomonossoff, Pier Luigi Fiori, Robert Atterbury, Matteo Rossi, Marco Lalle   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

Journal of Translational Medicine, 2019
Background In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epitopes.
Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch, Peter Johannes Holst   +3 more
doaj   +1 more source

Optimizing the synthesis and purification of MS2 virus like particles

Scientific Reports, 2021
Introducing bacteriophage MS2 virus-like particles (VLPs) as gene and drug delivery tools increases the demand for optimizing their production and purification procedure.
Khadijeh Hashemi, Mohammad Mahdi Ghahramani Seno, Mohammad Reza Ahmadian, Bizhan Malaekeh-Nikouei, Mohammad Reza Bassami, Hesam Dehghani, Amir Afkhami-Goli   +6 more
doaj   +1 more source

APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis [PDF]

, 2013
2A oligopeptide sequences (“2As”) mediate a cotranslational recoding event termed “ribosome skipping.” Previously we demonstrated the activity of 2As (and “2A-like sequences”) within a wide range of animal RNA virus genomes and non-long terminal repeat ...
Sukhodub, Andriy, Ryan, MD, De Felipe, Pablo, Ruan, L, Odon, Valerie Marie Nathalie, de Felipe, P, Sukhodub, A, Luke, Garry Alec, Ruan, Lin, Escuin-Ordinas, H, Roulston, Claire, Odon, V, Ryan, Martin Denis, Brown, JD, Roulston, C, Brown, Jeremy, Luke, GA, Escuin, Helena   +17 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Arctic-like Rabies Virus, Bangladesh

Emerging Infectious Diseases, 2012
Arctic/Arctic-like rabies virus group 2 spread into Bangladesh ≈32 years ago. Because rabies is endemic to and a major public health problem in this country, we characterized this virus group.
Khondoker Mahbuba Jamil, Kamruddin Ahmed, Moazzem Hossain, Takashi Matsumoto, Mohammad Azmat Ali, Sohrab Hossain, Shakhawat Hossain, Aminul Islam, Mohammad Nasiruddin, Akira Nishizono   +9 more
doaj   +1 more source

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Hui Wang, Tamas Dalmay, Kazusato Ohshima, Walsh, John A., Linfeng Huang, Ohshima, Kazusato, Wang, Hui, Denise W. Pallett, Pallett, Denise W., Liang Wang, Li, Zhigang, Thien Ho, Zhigang Li, John A. Walsh, Huang, Linfeng, Ho, Thien, Wang, Liang, Dalmay, Tamas   +17 more
core   +1 more source