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Bioengineering virus‐like particles as vaccines
Biotechnology and Bioengineering, 2013ABSTRACTVirus‐like particle (VLP) technology seeks to harness the optimally tuned immunostimulatory properties of natural viruses while omitting the infectious trait. VLPs that assemble from a single protein have been shown to be safe and highly efficacious in humans, and highly profitable.
Lua, Linda H. L. +5 more
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Annual Review of Microbiology, 1980
INTRODUCTION ......... .. ..... ..... ..... .. ... ....... 49 The Killer Character 50 The killing reaction ....... ..... 51 Other killer systems .. ......... ......... ..... ...... ...... 51 ScVas a model system 52 PHYSICAL PROPERTIES OF ScV PARTICLES 52 CAPSID POLYPEPTIDES ........ 55 ScV RNAs 56 Structure .. .
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INTRODUCTION ......... .. ..... ..... ..... .. ... ....... 49 The Killer Character 50 The killing reaction ....... ..... 51 Other killer systems .. ......... ......... ..... ...... ...... 51 ScVas a model system 52 PHYSICAL PROPERTIES OF ScV PARTICLES 52 CAPSID POLYPEPTIDES ........ 55 ScV RNAs 56 Structure .. .
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Enzyme Stabilization by Virus-Like Particles
Biochemistry, 2020The properties of enzymes packaged within the coat protein shell of virus-like particles (VLPs) were studied to provide a comprehensive assessment of such factors. Such entrainment did not seem to perturb enzyme function, but it did significantly enhance enzyme stability against several denaturing stimuli such as heat, organic solvents, and chaotropic ...
Soumen Das +3 more
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Transcutaneous vaccination with virus-like particles
Vaccine, 2006Virus-like particles (VLP) are inert, empty capsids of viruses, which contain no DNA/RNA from the virus itself. However they retain the structure of a virus and they can be engineered to have antigens attached. We have constructed VLP, derived from Rabbit hemorrhagic disease virus, and shown they are highly immunogenic.
Young, Sarah +5 more
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Structures of virus and virus-like particles
Current Opinion in Structural Biology, 2000Virus structures continue to be the basis for mechanistic virology and serve as a paradigm for solutions to problems concerning macromolecular assembly and function in general. The use of X-ray crystallography, electron cryomicroscopy and computational and biochemical methods has provided not only details of the structural folds of individual viral ...
J E, Johnson, W, Chiu
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Virus-like particles in human milk
Cancer, 1971Human milk from 59 women was studied by electron microscopy for the presence of viruslike particles. 2 types of viruslike particles were seen: 1) a small particle 20-40 mM and 2) a larger particle closely resembling the murine oncogenic ribonucleic acid virus.
W F, Feller, H C, Chopra
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Hybrid Ty Virus-Like Particles
International Reviews of Immunology, 1994Vaccines need to activate antigen presenting cells, overcome genetic restriction in T-cell responses and elicit both T and B memory cells. In order to produce recombinant vaccines which can do this, considerable effort has been put into developing particulate antigen presentation systems to generate polyvalent, high molecular weight antigens which ...
S E, Adams +3 more
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Meningoencephalitis with toroidal virus-like particles
Acta Neuropathologica, 1975A previously healthy middle aged man died following a 6 month illness which presented with middle ear symptoms, apparently resolved, and then 2 months later manifested as encephalitis. The illness was characterized initially by depression and intellectual deterioration. No family member or working associate was affected. The clinical diagnosis of viral
H C, Powell, A I, Braude, P W, Lampert
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Virus-like particles in Leishmania parasites
Nature, 1974VIRUSES or virus-like particles (VLPs) have been found in Entamoeba histolytica1, in the amoeboflagellate Naegleria gruberi2 and in malaria parasites3–5, but there have been no reports as yet of such organisms being found in the Trypanosomatidae. During investigations on the ultrastructure of various members of the genus Leishmania, however, VLPs have ...
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