Results 131 to 140 of about 5,701,493 (405)
Molecular Oncology, EarlyView.Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores +14 more
wiley +1 more source
A small molecule drug candidate targeting SARS-CoV-2 main protease [PDF]
arXiv, 2020 A new coronavirus identified as SARS-CoV-2 virus has brought the world to a state of crisis, causing a major pandemic, claiming more than 433,000 lives and instigating major financial damage to the global economy. Despite current efforts, developing safe and effective treatments remains a major challenge.
arxiv
Densovirus induces winged morphs in asexual clones of the rosy apple aphid, Dysaphis plantaginea [PDF]
, 2009 Winged morphs of aphids are essential for their dispersal and survival. We discovered that the production of the winged morph in asexual clones of the rosy apple aphid, Dysaphis plantaginea, is dependent on their infection with a DNA virus, Dysaphis ...
Ban +16 more
core +2 more sources
Adeno-Associated Virus (AAV) as a Vector for Gene Therapy
BioDrugs, 2017 There has been a resurgence in gene therapy efforts that is partly fueled by the identification and understanding of new gene delivery vectors. Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA to target cells ...
M. Naso +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits +7 more
wiley +1 more source
Protecting Anti-virus Programs From Viral Attacks [PDF]
arXiv, 2013 During a fight between viruses and anti-viruses it is not always predictable that the anti-virus is going to win. There are many malicious viruses which target to attack and paralyze the anti-viruses. It is necessary for an anti-virus to detect and destroy the malware before its own files are detected and destroyed by the malware.
arxiv
Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein [PDF]
, 1995 Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease.
Bertagnoli, Stéphane +9 more
core +2 more sources
Complete Replication of Hepatitis C Virus in Cell Culture
Science, 2005 Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
B. Lindenbach +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source