Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Viruses infecting carnations and dianthus species in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Horticultural Science at Massey University [PDF]
, 1975 Five viruses were detected in commercial carnations and these and a further four occurred in Dianthus species from gardens. Carnation mottle virus (CarMV) and carnation etched ring virus (CERV-50) were widespread in commercial carnations; arabis mosaic ...
Bennett, Peter Roger
core
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Navigating Virology’s Frontiers in Africa: Global Virus Network 2024 Durban Meeting
VirusesThe Global Virus Network (GVN) is a voluntary consortium of virology laboratories and affiliated scientists that seek to prevent and control global viral threats.
Maggie L. Bartlett +3 more
doaj +1 more source
Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage
eLife, 2015 Molecular mechanisms underlying substrate recognition and cleavage by Escherichia coli RseP, which belongs to S2P family of intramembrane-cleaving proteases, remain unclear.
Koichiro Akiyama +5 more
doaj +1 more source
Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015.
MMWR. Morbidity and mortality weekly report, 2016 In early 2015, an outbreak of Zika virus, a flavivirus transmitted by Aedes mosquitoes, was identified in northeast Brazil, an area where dengue virus was also circulating.
L. Schuler‐Faccini +14 more
semanticscholar +1 more source
Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]
, 1980 Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet +27 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Accelerating the Tempo of the Segmentation Clock by Reducing the Number of Introns in the Hes7 Gene
Cell Reports, 2013 Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing.
Yukiko Harima +4 more
doaj +1 more source