Results 201 to 210 of about 599,985 (268)

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Peculiar Cat with Many Lives: PUMA in Viral Infections. [PDF]

Cells
Wyżewski Z, Stępkowska J, Pruchniak P, Niedzielska A, Gregorczyk-Zboroch KP, Mielcarska MB.   +5 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

The Dual Role of Nrf2 Signaling in Virus Infections: Antiviral Guardian or Proviral Accomplice? [PDF]

Pathogens
Sahoo BR, Pandey KK, Pattnaik AK.
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Orchestrating immunopathology: the spectrum of programmed cell death pathways co-opted by influenza a virus in pulmonary immunity. [PDF]

Front Immunol
Luo Y, Xiang L, He Q, Gao Y, Zheng C, Yao H.   +5 more
europepmc   +1 more source

N6-methyladenosine modification of FZR1 mRNA positively regulates antiviral innate immunity by targeting the MAVS-TRAF3/6 axis. [PDF]

Proc Natl Acad Sci U S A
Dou K, Hu Y, Li M, Xu J, Zhang W, Wang H, Cheng Q, Jiang Z, Chen L, Liu S, Chen K, Liu Y, Xiong H, Luo F, Hou W, Chen S.   +15 more
europepmc   +1 more source

Immune Cells at the Frontline of SFTSV Infection. [PDF]

J Microbiol Biotechnol
Park S, Kim C.
europepmc   +1 more source

Pathogenesis of chikungunya arthritis: A scoping review. [PDF]

PLOS Glob Public Health
Rankin M, Pillay S, Ramiah J, Marais L.
europepmc   +1 more source