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Advanced Science, EarlyView.An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz +10 more
wiley +1 more source
Oropouche virus glycoprotein topology and cellular requirements for virus assembly
, 2020 Barbosa NS +4 more
europepmc +1 more source
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Current Opinion in Structural Biology, 1994
Abstract A wide variety of structural and biophysical techniques have been used to study viral assembly pathways. For example, the use of three-dimensional electron microscopy has allowed the visualization of viral assembly intermediates, as well as mature capsids. More detailed views of small icosahedral viruses and viral proteins, such as proteases,
Phoebe L. Stewart, Roger M. Burnett
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Abstract A wide variety of structural and biophysical techniques have been used to study viral assembly pathways. For example, the use of three-dimensional electron microscopy has allowed the visualization of viral assembly intermediates, as well as mature capsids. More detailed views of small icosahedral viruses and viral proteins, such as proteases,
Phoebe L. Stewart, Roger M. Burnett
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Current Opinion in Structural Biology, 1999
Virus assembly is a term describing several areas of current research: protein-RNA recognition; the control of the formation of large complexes; and mechanisms of particle maturation. Our understanding of these processes is increasing as a result of the efforts of numerous studies.
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Virus assembly is a term describing several areas of current research: protein-RNA recognition; the control of the formation of large complexes; and mechanisms of particle maturation. Our understanding of these processes is increasing as a result of the efforts of numerous studies.
openaire +2 more sources
Self-assembled virus–membrane complexes
Nature Materials, 2004Anionic polyelectrolytes and cationic lipid membranes can self-assemble into lamellar structures ranging from alternating layers of membranes and polyelectrolytes to 'missing layer' superlattice structures. We show that these structural differences can be understood in terms of the surface-charge-density mismatch between the polyelectrolyte and ...
Lihua, Yang +6 more
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Virus protein assembly in microgravity
Advances in Space Research, 1993The coat of polyomavirus is composed of three proteins that can self-assemble to form an icosahedral capsid. VP1 represents 75% of the virus capsid protein and the VP1 capsomere subunits are capable of self assembly to form a capsid-like structure.
D, Chang +3 more
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Rabies Virus Assembly and Budding
2011Rabies virus (RABV) and other negative-strand RNA viruses are the causes of serious diseases in humans and animals worldwide. Assembly and budding are important late events in the replication cycles of these negative-strand RNA viruses that have received much attention in the past decade.
Atsushi, Okumura, Ronald N, Harty
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Assembly of adeno-associated virus
Virology, 1980Abstract The assembly of the defective parvovirus, adeno-associated virus (AAV), was studied by labeling DNA and protein precursors with [3H]thymidine or [35S]methionine, respectively. Virus particles were extracted from cell lysates and characterized by banding to equilibrium in CsCl gradients and by velocity sedimentation in neutral sucrose ...
M W, Myers, B J, Carter
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Bluetongue Virus Assembly and Morphogenesis
2006Like other members of the Reoviridae, bluetongue virus faces the same constraints on structure and assembly that are imposed by a large dsRNA genome. However, since it is arthropod-transmitted, BTV must have assembly pathways that are sufficiently flexible to allow it to replicate in evolutionarily distant hosts.
P, Roy, R, Noad
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