Results 21 to 30 of about 37,625 (260)

Genotipos circulantes del virus de la hepatitis C en Colombia

Biomédica: revista del Instituto Nacional de Salud, 2017
Introducción. La infección crónica por el virus de la hepatitis C es un problema de salud pública y se estima que hay más de 180 millones de personas infectadas en el mundo.
Óscar Santos, Alberto Gómez, Viviana Vizcaíno, María Consuelo Casas, María del Pilar Ramírez, Patricia Olaya   +5 more
doaj   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Estado actual de la epidemiologí­a, diagnóstico, tratamiento y control de la hepatitis C

Ciencia, Tecnología y Salud, 2017
La hepatitis C, infección producida por el virus de la hepatitis C (VHC), que se transmite por sangre, es la principal causa de hepatitis crónica, cirrosis y cáncer del hí­gado a nivel mundial.
Patricia Velez-Moller
doaj   +3 more sources

Caracterización epidemiológica y clínica de la cirrosis hepatica en un centro regional del caribe colombiano: clínica general del norte. Enero 2012 a marzo 2017

Biociencias, 2018
La cirrosis hepática es una de las enfermedades con mayor prevalencia y mortalidad en la población mundial; sus etiologías más importantes son de tipo alcohólica, el virus de la hepatitis B, el virus de la hepatitis C y la esteatosis hepática no ...
Edgardo Jose Escorcia Charri
doaj   +1 more source

Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity

Advanced Materials, EarlyView.
This work introduces an injectable mesoporous silica rod scaffold that confines lentiviral vectors to the injection site, enabling localized dendritic cell recruitment and transduction. The platform sustains antigen expression, promotes robust T‐cell activation, and enhances antitumor immunity.
Thanh Loc Nguyen, Yeon‐ju Kim, Jihye Im, Dong Kwang Min, Hyunsu Shin, Thuy An Trinh, Ngoc Man Phan, Min‐jeong Son, Ji‐yeon Shim, Ye‐lim Lee, Yujeong Ha, Kwang‐il Lim, Jaeyun Kim   +12 more
wiley   +1 more source

Transplante hepático en pacientes con cirrosis por VHB y VHC

Anales del Sistema Sanitario de Navarra, 2008
La cirrosis hepática asociada al virus C constituye la principal indicación de trasplante hepático en Europa y EEUU, representando en adultos hasta el 50% de las indicaciones, mientras que la cirrosis asociada al virus B representa alrededor del 10%. Las
J.F. Lucena, J.I. Herrero
doaj  

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Infecciones Oportunistas en Personas con el Virus de la Inmunodeficiencia Humana Paraguay 2010-2016

Revista de la Sociedad Científica del Paraguay, 2017
Determinar la seroprevalencia de infecciones oportunistas (Hepatitis A, Hepatitis B, Hepatitis C, Toxoplasmosis y Citomegalovirus) en personas con VIH (Virus de la Inmunodeficiencia Humana) que fueron diagnosticados e institucionalizados en el Programa ...
Anibal Kawabata, María E. León, Claudia Cabañas, Gladys López, Tania Samudio   +4 more
doaj  

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source