Results 41 to 50 of about 38,243 (258)

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, EarlyView.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Hallazgos clínicos, bioquímicos y morfológicos en 103 pacientes con anticuerpos contra el virus de la hepatitis C

Revista Cubana de Medicina, 1998
Se estudiaron 103 pacientes portadores de anticuerpos contra el virus de la hepatitis C detectado mediante el empleo del sistema diagnóstico cubano (Anti VHC, CIGB, La Habana).
Mirtha Infante Velázquez, Enrique Arús Soler, Anayda Fernández Naranjo, Bienvenido Grá Oramas   +3 more
doaj  

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Importancia del pesquisaje de hepatitis virales en el diseño de estrategias de vacunación

VacciMonitor, 2005
Se analiza de forma longitudinal la incidencia de hepatitis virales, así como las tasas de portadores del antígeno de superficie del virus de la hepatitis B (HBsAg) y de anticuerpos contra el virus de la hepatitis C, detectados en los programas de ...
Irina Valdivia, Rolando Ochoa, Janette Trujillo, Aurora Delahanty, Julio Ventura, Darién Ortega, Ariel Palenzuela, Carlos Silva   +7 more
doaj  

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Nuevos progresos en el enfrentamiento a la hepatitis C

Revista Médica Electrónica
RESUMEN El virus de la hepatitis C es la principal infección trasmitida por los derivados de la sangre en los Estados Unidos, con 3.2 millones de individuos infectados.
Alfredo Enrique Arredondo Bruce, Ion Prez Trujillo   +1 more
doaj  

El interferón en el tratamiento de la hepatitis C crónica Inmunobiología básica e inmunopatología del hígado Interferon treatment of chronic hepatitis C: Basic immunobiology and immunopathology of the liver

Revista Española de Sanidad Penitenciaria, 2013
Este artículo revisa los principales aspectos de la hepatitis C crónica (epidemiológicos y genómicos, relacionados con un mejor conocimiento molecular del ciclo vital del virus de la hepatitis C, VHC) y de modo notable la terapia estándar con interferón &
J.S. Mazana
doaj  

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Actualización en el tratamiento de la Hepatitis C

Acta Médica Peruana, 2012
La hepatitis C es una enfermedad infectocontagiosa causada por 6 genotipos del virus del virus del mismo nombre que pueder responder de manera distinta al tratamiento.
Javier Díaz Ferrer
doaj