Results 51 to 60 of about 40,781 (258)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Comportamiento del virus de hepatitis C en pacientes hemodializados

Acta Médica del Centro, 2018
Introducción: la infección por el virus de hepatitis C es frecuente en pacientes con insuficiencia renal crónica con o sin tratamiento hemodialítico; en ellos este agente patógeno es la principal causa de enfermedad hepática.
Hector Medellín Ramírez, Esther Lidia González González, Merlyn Arce Núñez, Antonio Moré Pérez, Victor Manuel López Mejia, Yenis Echevarria Garcia   +5 more
doaj  

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Intervención basada en pruebas diagnósticas para un enfoque integral de las infecciones de transmisión sexual Intervention based on diagnostic tests for a sexual transmitted diseases' integral approach

Revista Médica Electrónica, 2011
Se realizó un estudio transversal descriptivo en diversas comunidades del municipio Manicaragua para Identificar la infección por el Virus de Inmunodeficiencia Humana, Virus de Hepatitis B, Virus de Hepatitis C y Treponema pallidum en 448 personas ...
Ana Margarita Mayor Puerta, María de Lourdes Sánchez Álvarez   +1 more
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Infección por virus de la hepatitis b y c en pacientes de hemodiálisis Hepatitis B and Hepatitis C virus infections in patients on haemodialysis

Revista de Ciencias Médicas de Pinar del Río, 2008
Por la elevada incidencia y prevalencia de las hepatitis virales en los pacientes de hemodiálisis, se realizó un estudio observacional, descriptivo, prospectivo para conocer incidencia, prevalencia de virus de la hepatitis C (VHC) y de la hepatitis B (VHB), además factores de carácter objetivos.
Joachín Barrios Camba, Cristian Leyva de la Torre, NorKys J Chávez Moreno, Yahima Cabrera Yero, Diana Rosa Márquez Márquez   +4 more
openaire   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Successful treatment with telaprevir of post-transplant fibrosing cholestatic hepatitis C in an HIV co-infected patient

Acta Gastroenterológica Latinoamericana, 2015
La recurrencia de la hepatitis C post-trasplante hepático es la principal causa de pérdida del injerto en los pacientes coinfectados con el virus de la inmunodeficiencia humana (HIV).
Sebastián Marciano, Omar Andrés Galdame, Laura Alicia Barcan, Adrián Carlos Gadano   +3 more
doaj  

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Serología en hepatitis virales = Serology in viral hepatitis

Iatreia, 2011
Cuando ocurre infección por el virus de hepatitis A (VHA), virus de hepatitits B (VHB), virus de hepatitis C (VHC) virus de hepatitis D o virus de hepatitis E (VHE) el cuadro clínico y bioquímico es similar, por lo que se hace necesario recurrir a ...
Jaramillo Aristizábal, María Clara, García Rendón, María Valentina, Restrepo Gutiérrez, Juan Carlos   +2 more
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