Results 171 to 180 of about 1,501,773 (255)

Virus Elimination by Direct-Acting Antiviral Agents Impacts Glucose Homeostasis in Chronic Hepatitis C Patients. [PDF]

Front Endocrinol (Lausanne), 2021
Cheng CH, Chu CY, Chen HL, Lin IT, Wu CH, Lee YK, Bair MJ.   +6 more
europepmc   +1 more source

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source

The Key Importance of Screening Underprivileged People in Order to Achieve Global Hepatitis Virus Elimination Targets. [PDF]

Viruses
Gragnani L, Monti M, De Giorgi I, Zignego AL.   +3 more
europepmc   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Progress Toward Hepatitis C Virus Elimination among People Living with HIV-Hepatitis C Virus Coinfection in Canada. [PDF]

Can Liver J
El Sheikh MZ, Young J, Panagiotoglou D, Cooper C, Cox J, Martel-Laferrière V, Walmsley S, Klein MB.   +7 more
europepmc   +1 more source

Hepatitis C virus elimination: laying the foundation for achieving 2030 targets. [PDF]

Nat Rev Gastroenterol Hepatol, 2021
Dore GJ, Bajis S.
europepmc   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Cost-effectiveness and return on investment of hepatitis C virus elimination in China: A modelling study. [PDF]

Clin Mol Hepatol
Wu M, Ma J, Wang X, Li S, Tan C, Xie O, Li A, Lim AG, Wan X.   +8 more
europepmc   +1 more source