Results 181 to 190 of about 219,172 (259)

Feathered bioreactor: transforming a chicken egg into a recombinant protein biomanufacturing foundry. [PDF]

Poult Sci
Naim A, Sharma A, Ray SK, Nayak D.
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Advances in the application of recombinant herpesvirus-vectored vaccines in animal disease control. [PDF]

Front Microbiol
Guo J, Mei C, Sun X, Lin Q, Bu W, Xie S, Jiang B.   +6 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Bacteriophage P22 Virus-Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology. [PDF]

Plant Biotechnol J
Harding MD, Jackson MA, Gilding EK, Craik DJ, Sainsbury F, Lawrence N.   +5 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Structure-Function Engineering of Hydrogel-MOF Polymer Composites for Regenerative Wound Dressings with Emerging Antiviral Biointerface Functions. [PDF]

Gels
González-Lara IA, Hernández-Hernández NG, Usme-Duque LK, Martínez-Berlanga LA, Ortíz-Hernández GD, León-Campos MI, Puente-Urbina B, Medina-Morales MA, Loredo-Alcalá EI, Ríos-González LJ, Morales-Martínez TK, Arredondo-Valdés R, Romero-Galarza A, Cano-Salazar LF, Betancourt-Galindo R, González-Díaz MO, Rodríguez-Fuentes N, Enríquez-Medrano J, Soriano-Corral F, Rosales-Ibáñez R, Rodríguez-Navarrete A, Cabrera-Munguía DA, Claudio-Rizo JA.   +22 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Emergence and endemicity of arboviruses in Haiti: a review. [PDF]

IJID Reg
Louis R, Sakib SN, Fan ZH, Parker LA, Lednicky JA, Morris JG, De Rochars VMB.   +6 more
europepmc   +1 more source