Results 211 to 220 of about 105,888 (295)

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Tight junction protein claudin-1 is a novel internalization factor for swine enteric coronaviruses infection. [PDF]

mBio
Li Z, Chen J, Chen Y, Hu S, Li H, Li L, Xue M, Feng L.   +7 more
europepmc   +1 more source

International BioInformatics Workshop on Virus Evolution and Molecular Epidemiology

Infection, Genetics and Evolution, 2013
Philippe, Lemey, Maja, Stanojevic, Anne-Mieke, Vandamme   +2 more
openaire   +2 more sources

Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non‐Human Primates

Advanced Science, EarlyView.
This study demonstrates multimodal integration in non‐human primates, combining large‐scale, high‐density electrophysiology using Smart Dura with optical techniques such as multiphoton imaging (MPI), photothrombotic lesioning, optical coherence tomography angiography (OCTA), wide‐field intrinsic signal optical imaging (ISOI), and optogenetics.
Nari Hong, Sergio Montalvo Vargo, Gaku Hatanaka, Zhaoyu Gong, Noah Stanis, Jasmine Zhou, Tiphaine Belloir, Ruikang K. Wang, Wyeth Bair, Maysamreza Chamanzar, Azadeh Yazdan‐Shahmorad   +10 more
wiley   +1 more source

CD4 Molecule Plays an Important Role in the Inflammatory Response Induced by Japanese Encephalitis Virus Infection. [PDF]

Vet Sci
Li X, Yang Y, Liu X, Dai Y, Gu Y, Zhang R, Li J, Chen H, Zheng Y, Wu R.   +9 more
europepmc   +1 more source

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

Endophilin mediated endocytosis and epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells. [PDF]

PLoS Pathog
Sharma P, Tanwar M, Choudhary E, Sundaram NM, Ojha D, Mishra L, Nain M, Rode A, Prasad VM, Vrati S, Kalia M.   +10 more
europepmc   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

BMV and CCMV-Based Viral Nanoparticles for Delivery of <i>N</i>‑Desmethyl-Tamoxifen as Treatment of Triple-Negative Breast Cancer. [PDF]

ACS Omega
Loredo-García E, Fournier PGJ, Herrera-Hernandez MM, Chauhan K, Rodriguez-Hernandez AG, Vazquez-Duhalt R, Cadena-Nava RD.   +6 more
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source