Results 241 to 250 of about 105,888 (295)

Netrin-1 inhibits the attachment and internalization of Hepatitis B virus for hepatocyte infection. [PDF]

PLoS Pathog
Wang Y, Murai K, Ishida A, Kawasaki N, Kuroki K, Li YY, Sato Y, Miura Y, Takara K, Kong L, Shimakami T, Nio K, Higuchi Y, Suemizu H, Ito S, Yanagawa H, Kaneko S, Yamashita T, Honda M.   +18 more
europepmc   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Targeting of Kaposi's sarcoma-associated herpesvirus by immunotoxins directed against the viral G protein-coupled receptor, ORF74.

Biomed Pharmacother
Kildedal DF, Drzazga AK, Sharma A, Berg C, Winther AN, Krogh-Hansen L, Gustavsson M, Kragelund BB, Våbenø J, Lagunoff M, Tsutsumi N, Kledal TN, Jeppesen MG, Rosenkilde MM.   +13 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Development of the reverse genetics system for viral hemorrhagic septicemia virus genotype IVa and its application in antiviral compound screening. [PDF]

Virol Sin
Huang H, Lu X, Hong T, Chen Y, Yi M, Jia K.   +5 more
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus. [PDF]

Nat Commun
Torii S, Lord JS, Lavina M, Prot M, Lecuyer A, Diagne CT, Faye O, Faye O, Sall AA, Bonsall MB, Simon-Lorière E, Montagutelli X, Lambrechts L.   +12 more
europepmc   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Cepharanthine inhibits enterovirus entry by endolysosomal deacidification and exhibits protective activity in vivo. [PDF]

Antimicrob Agents Chemother
Weng T-C, Hsu B-Y, Kung S-H.
europepmc   +1 more source

Genome-scale CRISPR screen identifies host factors associated with bovine parainfluenza virus 3 infection. [PDF]

Virulence
Geng Y, Jiang C, Zhang H, Yang H, Peng Y, Chen Y, Hu C, Liu H, Li S, Chen H, Xie S, Guo A.   +11 more
europepmc   +1 more source