Results 31 to 40 of about 4,792 (218)

Rapid CRISPR/Cas9 Editing of Genotype IX African Swine Fever Virus Circulating in Eastern and Central Africa

Frontiers in Genetics, 2021
African swine fever virus (ASFV) is the etiological agent of a contagious and fatal disease of domestic pigs that has significant economic consequences for the global swine industry.
Hussein M. Abkallo, Nicholas Svitek, Bernard Oduor, Elias Awino, Sonal P. Henson, Samuel O. Oyola, Stephen Mwalimu, Nacrya Assad-Garcia, Walter Fuchs, Sanjay Vashee, Lucilla Steinaa   +10 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Mpox due to monkeypox virus clade Ia infection detected outside of Africa: a case study

Communications Medicine
Background Monkeypox virus clade Ia has historically been restricted to central Africa and primarily associated with zoonotic transmission. In February 2025, a symptomatic adult with recent travel to the Democratic Republic of the Congo presented to a ...
Cian Dowling-Cullen, Laura Fahey, Michael Carr, Brian Keogan, Josephine Hebert, Siti Mardhiah Muhamad Fauzi, Jane Stapleton, Allison Deane, Elizabeth O’Donoghue, Colette Reilly, Christine Kelly, Eavan G. Muldoon, Margaret O’Sullivan, Anne Sheahan, Suzanne Cotter, Mary O’Meara, Eoghan De Barra, Éamonn O’Moore, Keith Ian Quintyne, Cillian De Gascun, Áine O’Toole, Daniel Hare, Derval Igoe   +22 more
doaj   +1 more source

The machine learning model based on trajectory analysis of ribonucleic acid test results predicts the necessity of quarantine in recurrently positive patients with SARS-CoV-2 infection

Frontiers in Public Health, 2022
BackgroundSARS-CoV-2 patients re-experiencing positive nucleic acid test results after recovery is a concerning phenomenon. Current pandemic prevention strategy demands the quarantine of all recurrently positive patients.
Qi-Xiang Song, Zhichao Jin, Weilin Fang, Chenxu Zhang, Chi Peng, Min Chen, Xu Zhuang, Wei Zhai, Jun Wang, Min Cao, Shun Wei, Xia Cai, Lei Pan, Qingrong Xu, Junhua Zheng   +14 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Isolation of influenza C virus recombinants [PDF]

Journal of Virology, 1979
Recombinants between two different influenza C viruses were isolated. In MDCK (canine kidney) cells, one strain, C/JJ/50, caused lytic plaques, whereas C/JHG/66 virus did not produce clear plaques. From a mixed infection of MDCK cells with C/JHG/66 virus and UV-inactivated C/JJ/50 virus, clones were isolated which possessed the clear-plaque phenotype ...
V R, Racaniello, P, Palese
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Isolation and Characterization of Porcine Epidemic Diarrhea Virus G2c Strains Circulating in China from 2021 to 2024

Veterinary Sciences
Porcine epidemic diarrhea virus (PEDV) is a major pathogen responsible for viral diarrhea in pigs, causing particularly high mortality in neonatal piglets. In recent years, genetic variations in PEDV have resulted in alterations in both its virulence and
Xi Lu, Chen Chen, Zixuan Wang, Anding Zhang   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Molecular Surveillance and Whole Genomic Characterization of Bovine Rotavirus A G6P[1] Reveals Interspecies Reassortment with Human and Feline Strains in China

Veterinary Sciences
Group A rotavirus (RVA) is a leading causative agent of diarrhea in both young animals and humans. In China, multiple genotypes are commonly found within the bovine population.
Ahmed H. Ghonaim, Mingkai Lei, Yang Zeng, Qian Xu, Bo Hong, Dongfan Li, Zhengxin Yang, Jiaru Zhou, Changcheng Liu, Qigai He, Yufei Zhang, Wentao Li   +11 more
doaj   +1 more source