Results 131 to 140 of about 134,525 (341)

Marek’s disease virus-encoded microRNA-M6-5p facilitates viral latent infection by targeting histone demethylase KDM2B

Journal of Virology
Marek’s disease virus (MDV), a highly contagious and oncogenic avian alphaherpesvirus, establishes a latent infection primarily in CD4+ T cells. Latent infections are necessary for both persistent lifelong MDV infection and viral tumorigenesis. MicroRNAs
Linyi Zhou, Runan Zhu, Bo Jiang, Jing Cheng, Wenxiao Liu, Yongxiu Yao, Yongqing Li   +6 more
doaj   +1 more source

Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation. [PDF]

Viruses, 2021
Murata T, Sugimoto A, Inagaki T, Yanagi Y, Watanabe T, Sato Y, Kimura H.   +6 more
europepmc   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

User privacy prevention model using supervised federated learning‐based block chain approach for internet of Medical Things

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract This research focuses on addressing the privacy issues in healthcare advancement monitoring with the rapid establishment of the decentralised communication system in the Internet of Medical Things (IoMT). An integrated blockchain homomorphic encryption standard with an in‐build supervised learning‐based smart contract is designed to improvise ...
Chandramohan Dhasarathan, Mohammad Kamrul Hasan, Shayla Islam, Salwani Abdullah, Shailesh Khapre, Dalbir Singh, Abdulaziz A. Alsulami, Ali Alqahtani   +7 more
wiley   +1 more source

MLL1 is regulated by KSHV LANA and is important for virus latency. [PDF]

Nucleic Acids Res, 2021
Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM.   +14 more
europepmc   +1 more source

Interferon alpha suppresses alphaherpesvirus immediate early protein levels in sensory neurons, leading to the establishment of a latent infection [PDF]

, 2010
Alphaherpesviruses are a subfamily of the herpesviruses containing closely related human and animal pathogens, including human herpes simplex virus (HSV-1) and porcine pseudorabies virus (PRV)
De Regge, Nick, Favoreel, Herman, Peelman, Luc, Van Opdenbosch, Nina, Van Poucke, Mario   +4 more
core  

Simian Immunodeficiency Virus Burden in Tissues and Cellular Compartments during Clinical Latency and AIDS [PDF]

, 1997
Todd A. Reinhart, Michael Rogan, David A. Huddleston, Dianne M. Rausch, Lee E. Eiden, Ashley T. Haase   +5 more
openalex   +1 more source

The anti-apoptotic function of HSV-1 LAT in neuronal cell cultures but not its function during reactivation correlates with expression of two small non-coding RNAs, sncRNA1&2.

PLoS Pathogens
Multiple functions are associated with HSV-1 latency associated transcript (LAT), including establishment of latency, virus reactivation, and antiapoptotic activity.
Jay J Oh, Ujjaldeep Jaggi, Kati Tormanen, Shaohui Wang, Satoshi Hirose, Homayon Ghiasi   +5 more
doaj   +1 more source

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

eLife
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein found that ICP34.5 can act as an antagonistic factor for the reactivation of HIV latency by herpes simplex virus type I ...
Ziyu Wen, Pingchao Li, Yue Yuan, Congcong Wang, Minchao Li, Haohang Wang, Minjuan Shi, Yizi He, Mingting Cui, Ling Chen, Caijun Sun   +10 more
doaj   +1 more source

DLK-Dependent Biphasic Reactivation of Herpes Simplex Virus Latency Established in the Absence of Antivirals. [PDF]

J Virol, 2022
Dochnal S, Merchant HY, Schinlever AR, Babnis A, Depledge DP, Wilson AC, Cliffe AR.   +6 more
europepmc   +1 more source