Results 91 to 100 of about 778,919 (247)
Prospects for prophylactic hepatitis C vaccines based on virus-like particles. [PDF]
, 2013 International audienceGiven the global prevalence and long-term complications of chronic hepatitis C virus (HCV) infection, HCV constitutes one of the greatest challenges to human health of this decade.
Beaumont, Elodie, Roingeard, Philippe
core +3 more sources
Virus-like particles as vaccine adjuvants
Molecular Biotechnology, 2001 Virus-like particles (VLPs) consist of one or more viral coat proteins that assemble into particles. They can be taken up by antigen presenting cells (APC), peptides derived from them are presented on MHC class I molecules at the cell surface, and thereby prime a CD8+ T cell response, either against the particle-forming protein itself (such as ...
openaire +3 more sources
Tomato spotted wilt virus glycoproteins induce the formation of endoplasmic reticulum- and Golgi-derived pleomorphic membrane structures in plant cells [PDF]
, 2008 Tomato spotted wilt virus (TSWV) particles are spherical and enveloped, an uncommon feature among plant infecting viruses. Previous studies have shown that virus particle formation involves the enwrapment of ribonucleoproteins with viral glycoprotein ...
Denecke, J. +5 more
core +2 more sources
Journal of Virology, 2019 The engagement of antiviral effector responses caused by viral infection is essential when using viruses or virus-like particles (VLPs) as an immunotherapeutic agent. Here, we compare the chemophysical and immunostimulatory properties of wild-type cowpea
Chao Wang, V. Beiss, N. Steinmetz
semanticscholar +1 more source
Harnessing Nanoparticles for Immunomodulation and Vaccines
Vaccines, 2017 The first successful use of nanoparticles (NPs) for vaccination was reported almost 40 years ago with a virus-like particle-based vaccine against Hepatitis B.
Ariane C. Gomes +2 more
doaj +1 more source
A novel molecular carrier from Newcastle Disease Virus. [PDF]
, 2003 Various kinds of carrier molecules have been used to deliver nucleic acids, drugs. vaccines and other important compounds. A molecular carrier for immunogenic peptides has been developed which can be used for the development of multicomponent ...
Universiti Putra Malaysia, Research Management Centre
core
Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
Vaccines, 2018 Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in
Mona O. Mohsen +3 more
semanticscholar +1 more source
Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family
Vaccines, 2019 Viruses in the Flaviviridae family are important human and animal pathogens that impose serious threats to global public health. This family of viruses includes emerging and re-emerging viruses, most of which are transmitted by infected mosquito or tick ...
Shu Hui Wong +5 more
doaj +1 more source
A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]
, 2016 A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul +13 more
core +2 more sources
Scientific Reports, 2017 Several Zika virus (ZIKV) vaccine candidates have recently been described which use inactivated whole virus, DNA or RNA that express the virus’ Envelope (E) glycoprotein as the antigen.
Ming Yang +3 more
semanticscholar +1 more source