Results 141 to 150 of about 2,319 (231)

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Interventions for preventing dengue: a mapping review. [PDF]

Cochrane Database Syst Rev
Choi L, Guedes Alcoforado Aguiar B, Wisniewski S, Modesto ACF, Lopes LP, Salvador Carrillo J, Moura MDG, Noel-Storr A, Parker R, Lopes LC.   +9 more
europepmc   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity-Dependent in Adult Rats. [PDF]

Glia
Mountadem S, Hilal ML, Pommier D, Arnouil D, Langlais VC, Simon V, Amadio A, Miegebielle M, Marais S, Joséphine C, Cannich A, Varilh M, Bourel J, Cota D, Marsicano G, Bemelmans AP, Ciofi P, Oliet SHR, Panatier A.   +18 more
europepmc   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids. [PDF]

iScience
Gaston-Breton R, Bouzid A, Antipushina E, Costa N, Sarkadi B, Apati A, Harati R, Sharaev M, Armengaud J, Disdier C, Hamoudi R, Mabondzo A.   +11 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Ecological drivers of arboviral disease risk: Vector-host interfaces in a Mediterranean wetland of Northeastern Spain. [PDF]

PLoS Negl Trop Dis
Froxán-Grabalosa J, Mariani S, Cerecedo-Iglesias C, Richter-Boix A, Torner AO, Pla M, Brotons L, Bartumeus F.   +7 more
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Histological guided treatment in paediatric patients presenting with severe left ventricular dysfunction. [PDF]

Eur J Pediatr
Dolader P, Juzga Corrales DC, Esmel-Vilomara R, Daina C, Izquierdo-Blasco J, Fernandez E, Garrido-Pontnou M, Navarro A, Camacho J, Fidalgo A, Sánchez-Salmador R, Escudero F, Sorli M, Betrian-Blasco P, Roses-Noguer F, Gran F.   +15 more
europepmc   +1 more source