Results 311 to 320 of about 3,645,587 (361)

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Reduction in Acute Bee Paralysis Virus Infection and Mortality in Honey Bees (<i>Apis mellifera</i>) by RNA Interference Technology. [PDF]

Insects
Ferrufino C, Scannapieco A, Russo RM, Gonzalez FN, Salvador R, Dus Santos MJ.   +5 more
europepmc   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice. [PDF]

Sci Rep
Wilke J, Ntolkeras A, Gastaldi VD, Borowski K, Teegen B, Stöcker W, Lühder F, Nave KA, Ehrenreich H.   +8 more
europepmc   +1 more source

Microbiome Single Cell Atlases Generated with a Commercial Instrument

Advanced Science, EarlyView.
Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li, Linfeng Xu, Benjamin Demaree, Cecilia Noecker, Jordan E. Bisanz, Daniel W. Weisgerber, Cyrus Modavi, Peter J. Turnbaugh, Adam R. Abate   +8 more
wiley   +1 more source

A Fluorescent Reporter Virus Toolkit for Interrogating Enterovirus Biology and Host Interactions. [PDF]

Viruses
Martínez-Pérez M, Velandia-Álvarez S, Vidal-Verdú C, Álvarez-Rodríguez B, Geller R.   +4 more
europepmc   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

A comparative performance evaluation of 12 HIV-1 viral load testing asssays: advancing the clinical application of HIV-1 nucleic acid testing in China. [PDF]

Microbiol Spectr
Wang Y, Pan P, Xing W, Zhang X, Han B, Jin C.   +5 more
europepmc   +1 more source

Epidemiological and Molecular Surveillance of Aichi Virus A at Different Stages of Sewage Treatment: A One-Year Study in the Southeast of Brazil. [PDF]

Viruses
do Nascimento MCA, Rosa CR, Demoliner M, Geraldini DB, Campos GRF, Quevedo DM, Miceli RN, Spilki FR, Araújo JP, Calmon MF, Rahal P.   +10 more
europepmc   +1 more source