Results 81 to 90 of about 3,645,587 (361)

Methods for virus recovery from environmental surfaces to monitor infectious viral contamination

Environment International, 2023
Accurate quantification of infectious contaminants on environmental surfaces, particularly infectious viruses, is essential for contact transmission risk assessment; however, difficulties in recovering viruses from surfaces using swabs complicates this ...
Hajime Miyazaki, Ryohei Hirose, Mikako Ichikawa, Hiroki Mukai, Katsuma Yamauchi, Takaaki Nakaya, Yoshito Itoh   +6 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Hepatitis C virus quantification in serum and saliva of HCV-infected patients.

Memórias do Instituto Oswaldo Cruz, 2012
The hepatitis C virus (HCV) can be detected in blood and other bodily fluids, such as saliva, semen and gastric juices. The aim of this study was to compare the HCV viral loads in the serum and saliva of infected patients.
G. Menezes, F. A. Pereira, César Augusto Barros Duarte, T. Carmo, Hermes Pedreira da Silva Filho, M. A. Zarife, M. Krieger, E. Reis, M. Reis   +8 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

One-step and wash-free multiplexed immunoassay platform based on bioinspired photonic barcodes

Engineered Regeneration, 2023
Multiplex, rapid and accurate virus quantification plays a great value in biomedical detection. Here, a novel one step, wash-free immunoassay platform based bioinspired PhC barcodes for multiplexed virus quantification was explored.
Dagan Zhang, Yuze Wang, Junqi Zhao, Xueqin Li, Yuanyang Zhou, Sen Wang   +5 more
doaj  

The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]

, 1984
Limiting dilution (LD) analysis with two modifications, the expansion and the restimulation LD assay, led to the detection and quantification of two distinct in vivo maturation stages within the lineage of virus- specific self-restricted CTL after ...
Keil, Günther M., Koszinowski, Ulrich H., Reddehase, Matthias J.   +2 more
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Quantification and molecular characterization of the feline leukemia virus A receptor

Infection, Genetics and Evolution, 2011
Virus receptors and their expression patterns on the cell surface determine the cell tropism of the virus, host susceptibility and the pathogenesis of the infection. Feline thiamine transport protein 1 (fTHTR1) has been identified as the receptor for feline leukemia virus (FeLV) A.
Helfer-Hungerbuehler, A K, Cattori, V, Bachler, B, Hartnack, S, Riond, B, Ossent, P, Lutz, H, Hofmann-Lehmann, R   +7 more
openaire   +4 more sources

Clinical Utility of Quantitative Hbsag in Chronic Hepatitis B Infection

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
The prevalence of hepatitis B infection in Indonesia is still alarming, while its therapies cannot eradicate the virus and only aim for long term viral suppression.
Poernomo Boedi Setiawan, Ummi Maimunah, Khairu Zein   +2 more
doaj   +1 more source

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus [PDF]

, 2014
In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been ...
Hague, Charlotte V., Liefhebber, Jolanda M.P., McLauchlan, John, Wakelam, Michael J.O., Zhang, Qifeng   +4 more
core   +1 more source