Results 221 to 230 of about 1,825,715 (311)

Monkeypox virus replication and host response in vaginal and ectocervical epithelial cells. [PDF]

Virulence
Mariotti D, Picarone L, D'Auria A, Rosa L, Valeriani V, Pietrucci D, Meschi S, Carletti F, Mazzotta V, Antonelli G, Girardi E, Scagnolari C, Chillemi G, Antinori A, Maggi F, Matusali G.   +15 more
europepmc   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

TRIM21 is a molecular rheostat for influenza A virus replication

Teo QW, Lv H, Pholcharee T, Chen X, Ramadin V, Mao KJ, Huang JJ, Rivera-Cardona J, Zhu J, Huan YW, Shao EK, Tun HM, Brooke CB, Radoshevich L, Sanyal S, Wu NC.   +15 more
europepmc   +1 more source

TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-M. [PDF]

Emerg Microbes Infect
He H, Liang W, Lin W, Wang Y, Su R, Wang Y, Huang S, Luo J, Guo X.   +8 more
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

JMJD6-mediated epigenetic silencing of innate immunity promotes pseudorabies virus replication. [PDF]

J Virol
Ming S-L, Chai Y-J, Yang J-M, Xing J-Y, Zhang S-J, He S-N, Lu Q-X, Wang J, Pan J-J, Lu W-F, Zeng L, Chu B-B.   +11 more
europepmc   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene-Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis. [PDF]

FASEB J
Luo J, Guo K, Xiao F, Wang R, Guo J, Ren Q, Zhao S, Obaid MK, Guan G, Yin H.   +9 more
europepmc   +1 more source

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source

Cathepsin C Restricts Influenza A Virus Replication and Is Associated with Suppression of the PI3K-AKT Signaling Pathway. [PDF]

Viruses
Zhu Y, Si L, Cao Z, Song H, Yang A, Wang X, Qiu Y, Gao C, Zhou G, Cao P.   +9 more
europepmc   +1 more source