Results 221 to 230 of about 3,660,140 (254)

Ensuring children's inclusion in the Bundibugyo Ebola response: Striving to do better this time. [PDF]

PLOS Glob Public Health
Kalmus Eliasz M, Adeyemi-Lawal M, D'Mello Guyett L, Manno D, Myango B, Reges P, Russell N.   +6 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Advancing Chikungunya Prevention and Vaccination in Mexico: A Position Paper by the Immunization Committee of the Mexican Association of Pediatric Infectious Diseases. [PDF]

Vaccines (Basel)
Vázquez-Narváez JA, Avilés-Robles M, Espinosa-Sotero C, Martínez-Longoria CA, Moreno-Espinosa S, Reyes-Berlanga ML, Chacon-Cruz E.   +6 more
europepmc   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Targeting Epstein-Barr Virus for Cancer Vaccines: Recent Advances and Future Directions. [PDF]

Cancer Commun (Lond)
Lin G, Chen Z, Zhong Q, Sun C, Zeng MS.
europepmc   +1 more source

Comprehensive preclinical evaluation of second-generation miRNA-regulated Coxsackievirus B3-BHP: Potent antitumor efficacy and safety. [PDF]

Mol Ther Oncol
Sakashita Y, Miyamoto S, Sagara M, Ito S, Kobayashi Y, Momoda Y, Yano F, Eto K, Tani K, Murahashi M.   +9 more
europepmc   +1 more source

Chimeric SARS-CoV-2 vaccine vectors stably incorporating the functional glycoprotein of VSV. [PDF]

iScience
Kipfer ET, Schön J, Chami M, Finke S, Beer M, Hoffmann D, Otte F, Hauser D.   +7 more
europepmc   +1 more source

Synthetic Biology Strategies for the Development of Live Attenuated Influenza Viruses: Recent Advances and Applications. [PDF]

Viruses
Yang K, Yang G, Xia Y, Ou X.
europepmc   +1 more source